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Anti-CDKN2A / p16INK4a Antibody (aa50-150, DY488) LS-C141987

Ordering

Wt. Vol. Conc. Price
- 100 µl - $365
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular CDKN2A / p16INK4a Antibodies

Anti-CDKN2A / p16INK4a Antibody (N-Terminus) IHC-plus™ LS-B1347
Rabbit Polyclonal (IgG) to Human CDKN2A / p16INK4a
Human, Mouse, Rat
IHC - Paraffin, Western blot
Unconjugated
Immunohistochemistry Image
Anti-CDKN2A / p16INK4a Antibody (clone 1E12E10) IHC-plus™ LS-B5261
Mouse Monoclonal [clone 1E12E10] (IgG1) to Human CDKN2A / p16INK4a
Human, Mouse, Rat
IHC - Paraffin, Western blot, ELISA
Unconjugated
Immunohistochemistry Image
Anti-CDKN2A / p16INK4a Antibody (aa50-150) LS-C49180
Rabbit Polyclonal to Mouse CDKN2A / p16INK4a
Mouse
IHC - Paraffin, IHC - Frozen, ICC, Western blot, ELISA
Unconjugated
Western blot Image

100% Guaranteed 100% Guaranteed
Rabbit Polyclonal (IgG) to Mouse CDKN2A / p16INK4a
Mouse
IHC - Paraffin, IHC - Frozen, ICC, Western blot, ELISA (applications tested for the base form of this product only)
DY488 Conjugated

Details

Mouse CDKN2A / p16INK4a
Rabbit
Mouse (tested or 100% immunogen sequence identity)
Rat (at least 90% immunogen sequence identity)
IgG Polyclonal
DyLight 488. Also available Unconjugated or conjugated with Biotin, DY650, DY550.
Affinity purified
Unmodified

Applications

  • IHC - Paraffin (1 µg/ml)
  • IHC - Frozen
  • ICC (1 µg/ml)
  • Western blot (2 µg/ml)
  • ELISA (2 µg/ml)
  • (applications tested for the base form of this product only)

Specificity and Use

CDKN2A / p16INK4a antibody was raised against synthetic peptide conjugated to KLH, derived from a sequence within residues 50-150 of mouse p19ARF. [Swiss-Prot #P51480]. Percent identity by BLAST analysis: Rat (93%); Porcine (86%); Human (80%).
aa50-150
On Western blot the detects a band corresponding to p19ARF in mouse embryonic fibroblasts.
The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.

Packaging

50 mM sodium borate
Store at 4°C. Do not freeze.
For research use only.

About CDKN2A / p16INK4a

P42771 NM_000077 NP_000068.1

CDKN2A Antibody, ARF Antibody, Cdk4 inhibitor Antibody, CDK4 inhibitor p16-INK4 Antibody, INK4 Antibody, INK4A Antibody, Multiple tumor suppressor 1 Antibody, MTS-1 Antibody, MTS1 Antibody, p16-INK4 Antibody, p16-INK4A Antibody, p16INK4 Antibody, p19 Antibody, p14 Antibody, p16 Antibody, p16 INK4A Antibody, p16INK4A Antibody, p14ARF Antibody, TP16 Antibody, CDK4I Antibody, CDKN2 Antibody, CMM2 Antibody, MLM Antibody, p19ARF Antibody

Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes.

Western blot

Western blot
Detection of p19ARF in MEF lysate (25 ug) using antibody (2 ug/ml). This image was taken for the unconjugated form of this product. Other forms have not been tested.
 

Requested From: United States
Date Requested: 12/7/2016

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