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Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life.
Gene Name: | cyclin-dependent kinase inhibitor 1C (p57, Kip2) |
Synonyms: | CDKN1C, BWS, KIP2, IMAGE, p57Kip2, p57, p57 KIP2, Beckwith-Wiedemann syndrome, WBS, BWCR |
Target Sequences: | nm_000076 NP_000067.1 P49918 |
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