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Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation.
Gene Name: | cyclin-dependent kinase 8 |
Family/Subfamily: | Protein Kinase , CDC2/CDK |
Synonyms: | CDK8, Cell division protein kinase 8, Cyclin-dependent kinase 8, RGD1560888, CDK8 protein kinase, K35, Mediator complex subunit CDK8, Protein kinase K35 |
Target Sequences: | NM_001260 NP_001251.1 P49336 |
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