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Anti-CDK11A / CDC2L2 Antibody (aa730-780) LS-C56915

Ordering

Wt. Vol. Conc. Price
50 µg - 1 mg/ml $345
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular CDK11A / CDC2L2 Antibodies

Anti-CDK11A / CDC2L2 Antibody (aa730-780) LS-C56915
Rabbit Polyclonal to Human CDK11A / CDC2L2
Human
Western blot, Immunoprecipitation
Unconjugated
Western blot Image
Anti-CDK11A / CDC2L2 Antibody (aa50-100) LS-C78854
Rabbit Polyclonal (IgG) to Human CDK11A / CDC2L2
Human
Western blot
Unconjugated
Anti-CDK11A / CDC2L2 Antibody (C-Terminus) LS-C78855
Rabbit Polyclonal (IgG) to Human CDK11A / CDC2L2
Human
Western blot, Immunoprecipitation
Unconjugated

100% Guaranteed 100% Guaranteed
Rabbit Polyclonal to Human CDK11A / CDC2L2
Human
Western blot, Immunoprecipitation
Unconjugated

Details

Human CDK11A / CDC2L2
Rabbit
Human (tested or 100% immunogen sequence identity)
Mouse, Xenopus (at least 90% immunogen sequence identity)
Polyclonal
Unconjugated
Affinity purified
Unmodified

Applications

  • Western blot (1:10000 - 1:30000)
  • Immunoprecipitation

Specificity and Use

CDK11A / CDC2L2 antibody was raised against synthetic peptide corresponding to an epitope within amino acid residues 730-780 of human Cdk11 (GeneID 985).
aa730-780
Recognizes human Cdk11 (cyclin-dependent kinase 11), otherwise known as CDC2L2, a ubiquitously expressed member of the p34cdc2 protein kinase family involved in cell cycle regulation and apoptosis, and linked with tumorigenesis. Three major isoforms of Cdk11 identified are the full length gene product Cdk11p110 and the shorter polypeptides Cdk11p58 and Cdk11p46. Cdk11p110 is a component of RNA polymerase II containing complexes involved in transcriptional regulation, and is implicated in pre-mRNA splicing through interaction with the splicing factor RNPS1 (RNA-binding protein with serine-rich domain 1). Cdk11p58 has been linked with mitosis, cell cycle arrest and apoptosis, and recently implicated as a negative regulator of the androgen receptor (AR) as part of a cyclin D3/ Cdk11p58 complex. Cdk11p46 arises from the cleavage of Cdk11p110 and Cdk11p58 by caspases following the induction of apoptosis, and is linked with apoptotic progression.
Western Blot: LS-C56915 detects a band of approximately 120kD in HeLa cell lysates.

Packaging

Tris-citrate/phosphate, 0.09% sodium azide.
Long term: -20°C; Short term: -20°C
For research use only.

About CDK11A / CDC2L2

Q9UQ88 NP_076916.2

CDK11A Antibody, CDK11 Antibody, CDC2L3 Antibody, Cell division cycle 2-like 3 Antibody, Cyclin-dependent kinase 11A Antibody, CDK11-p110 Antibody, CDK11-p58 Antibody, PITSLRE A Antibody, PITSLRE B Antibody, CDC2L2 Antibody, CDK11-p46 Antibody, Cell division cycle 2-like 2 Antibody, p58GTA Antibody, PITSLRE Antibody, PITSLRE protein kinase beta Antibody, PITSLREB Antibody

CDK11A / CDC2L2 is a member of the p34Cdc2 protein kinase family. p34Cdc2 kinase family members are known to be essential for eukaryotic cell cycle control. This gene is in close proximity to CDC2L1, a nearly identical gene in the same chromosomal region. The gene loci including this gene, CDC2L1, as well as metalloprotease MMP21/22, consist of two identical, tandemly linked genomic regions, which are thought to be a part of the larger region that has been duplicated.

Western blot

Western blot
Detection of human CDK11 in whole cell lysates (WCL) of HeLa cells by Western blotting with Rabbit anti-Human CDK11 (LS-C56915) and by immunoprecipitation with LS-C56915. the immunoprecipitate was resolved on a 4-20% gel , subsequently Coomassie stained and the CDK11 band was confirmed by mass spectrometry.
 

Requested From: United States
Date Requested: 12/8/2016

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