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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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CDK11A / CDC2L2 Antibody (aa730‑780) LS‑C56915 Best Seller
CDC2L2 antibody LS-C56915 is an unconjugated rabbit polyclonal antibody to human CDC2L2 (CDK11A). Validated for IP and WB.
Catalog
Size
Price
LS-C56915-50
50 µg (1 mg/ml)
Unavailable

Popular CDK11A / CDC2L2 Products

Western blot of Cyclin-dependent kinase 11A antibody at 2 ug/ml + 293T whole cell lysate. Secondary: Goat polyclonal to Rabbit IgG at 1:15000 dilution. Predicted band size: 87 kDa. Observed band size: 87 kDa.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Species: Human
Applications: IHC, Western blot, ELISA
Detection of Human CDK11 by Immunohistochemistry. Sample: FFPE section of human stomach adenocarcinoma. Antibody: Affinity purified rabbit anti-CDK11 used at a dilution of 1:250. Detection: DAB.
Species: Human, Mouse, Rat, Dog, Chicken, Xenopus
Applications: IHC, IHC - Paraffin, Immunofluorescence
Detection of Human CDK11 by Immunohistochemistry. Sample: FFPE section of human stomach carcinoma. Antibody: Affinity purified rabbit anti-CDK11 used at a dilution of 1:1000 (1 ug/ml).
Species: Human, Mouse, Rat, Dog, Chicken, Xenopus
Applications: IHC, IHC - Paraffin, Immunofluorescence, Western blot, Immunoprecipitation
Antibody
Species: Human
Applications: Immunofluorescence, ELISA

Product Description

CDC2L2 antibody LS-C56915 is an unconjugated rabbit polyclonal antibody to human CDC2L2 (CDK11A). Validated for IP and WB.
About CDK11A / CDC2L2
CDK11A / CDC2L2 is a member of the p34Cdc2 protein kinase family. p34Cdc2 kinase family members are known to be essential for eukaryotic cell cycle control. This gene is in close proximity to CDC2L1, a nearly identical gene in the same chromosomal region. The gene loci including this gene, CDC2L1, as well as metalloprotease MMP21/22, consist of two identical, tandemly linked genomic regions, which are thought to be a part of the larger region that has been duplicated. Q9UQ88 NP_076916.2

CDK11A Antibody, CDK11 Antibody, CDC2L3 Antibody, Cell division cycle 2-like 3 Antibody, Cyclin-dependent kinase 11A Antibody, CDK11-p110 Antibody, CDK11-p58 Antibody, PITSLRE A Antibody, PITSLRE B Antibody, CDC2L2 Antibody, CDK11-p46 Antibody, Cell division cycle 2-like 2 Antibody, p58GTA Antibody, PITSLRE Antibody, PITSLRE protein kinase beta Antibody, PITSLREB Antibody


Specifications

Target
Human CDK11A / CDC2L2
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Predicted
Mouse, Xenopus (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Affinity purified
Modifications
Unmodified
Applications
  • Western blot (1:10000 - 1:30000)
  • Immunoprecipitation
Immunogen
CDK11A / CDC2L2 antibody was raised against synthetic peptide corresponding to an epitope within amino acid residues 730-780 of human Cdk11 (GeneID 985).
Epitope
aa730-780
Specificity
Recognizes human Cdk11 (cyclin-dependent kinase 11), otherwise known as CDC2L2, a ubiquitously expressed member of the p34cdc2 protein kinase family involved in cell cycle regulation and apoptosis, and linked with tumorigenesis. Three major isoforms of Cdk11 identified are the full length gene product Cdk11p110 and the shorter polypeptides Cdk11p58 and Cdk11p46. Cdk11p110 is a component of RNA polymerase II containing complexes involved in transcriptional regulation, and is implicated in pre-mRNA splicing through interaction with the splicing factor RNPS1 (RNA-binding protein with serine-rich domain 1). Cdk11p58 has been linked with mitosis, cell cycle arrest and apoptosis, and recently implicated as a negative regulator of the androgen receptor (AR) as part of a cyclin D3/ Cdk11p58 complex. Cdk11p46 arises from the cleavage of Cdk11p110 and Cdk11p58 by caspases following the induction of apoptosis, and is linked with apoptotic progression.
Usage
Western Blot: LS-C56915 detects a band of approximately 120kD in HeLa cell lysates.
Presentation
Tris-citrate/phosphate, 0.09% sodium azide.
Storage
Short term: -20°C; Long term: -20°C.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Western blot

Detection of human CDK11 in whole cell lysates (WCL) of HeLa cells by Western blotting with Rabbit anti-Human CDK11 (LS-C56915) and by immunoprecipitation with LS-C56915. the immunoprecipitate was resolved on a 4-20% gel , subsequently Coomassie stained and the CDK11 band was confirmed by mass spectrometry.
Detection of human CDK11 in whole cell lysates (WCL) of HeLa cells by Western blotting with Rabbit anti-Human CDK11 (LS-C56915) and by immunoprecipitation with LS-C56915. the immunoprecipitate was resolved on a 4-20% gel , subsequently Coomassie stained and the CDK11 band was confirmed by mass spectrometry.

Western blot

Detection of human CDK11 in whole cell lysates (WCL) of HeLa cells by Western blotting with Rabbit anti-Human CDK11 (LS-C56915) and by immunoprecipitation with LS-C56915. the immunoprecipitate was resolved on a 4-20% gel , subsequently Coomassie stained and the CDK11 band was confirmed by mass spectrometry.
Detection of human CDK11 in whole cell lysates (WCL) of HeLa cells by Western blotting with Rabbit anti-Human CDK11 (LS-C56915) and by immunoprecipitation with LS-C56915. the immunoprecipitate was resolved on a 4-20% gel , subsequently Coomassie stained and the CDK11 band was confirmed by mass spectrometry.

Western blot

Detection of human CDK11 in whole cell lysates (WCL) of HeLa cells by Western blotting with Rabbit anti-Human CDK11 (LS-C56915) and by immunoprecipitation with LS-C56915. the immunoprecipitate was resolved on a 4-20% gel , subsequently Coomassie stained and the CDK11 band was confirmed by mass spectrometry.
Detection of human CDK11 in whole cell lysates (WCL) of HeLa cells by Western blotting with Rabbit anti-Human CDK11 (LS-C56915) and by immunoprecipitation with LS-C56915. the immunoprecipitate was resolved on a 4-20% gel , subsequently Coomassie stained and the CDK11 band was confirmed by mass spectrometry.

Western blot

Detection of human CDK11 in whole cell lysates (WCL) of HeLa cells by Western blotting with Rabbit anti-Human CDK11 (LS-C56915) and by immunoprecipitation with LS-C56915. the immunoprecipitate was resolved on a 4-20% gel , subsequently Coomassie stained and the CDK11 band was confirmed by mass spectrometry.
Detection of human CDK11 in whole cell lysates (WCL) of HeLa cells by Western blotting with Rabbit anti-Human CDK11 (LS-C56915) and by immunoprecipitation with LS-C56915. the immunoprecipitate was resolved on a 4-20% gel , subsequently Coomassie stained and the CDK11 band was confirmed by mass spectrometry.


Requested From: 
Date Requested: 6/18/2018

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