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Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C). Dephosphorylates SIRT2 around early anaphase. Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases.
Gene Name: | cell division cycle 14B |
Family/Subfamily: | Protein Phosphatase , CDC14 |
Synonyms: | CDC14B, CDC14 homolog B, Cdc14B1, Cdc14B2, Cell division cycle 14b, CDC14B3, HCDC14B |
Target Sequences: | NM_003671 NP_201588.1 O60729 |
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