Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Rat Monoclonal [clone YTS169.4] (IgG2b) to Mouse CD8A / CD8 Alpha
IHC - Frozen, Flow Cytometry, Cytotoxic Assay
Mouse CD8A / CD8 Alpha
Mouse (tested or 100% immunogen sequence identity)
IgG2b Monoclonal [YTS169.4]
IHC - Frozen
Flow Cytometry (0.2 µg/10E6 cells)
Specificity and Use
CD8A / CD8 Alpha antibody was raised against mouse Ly-2 thymocytes.
Purified anti-CD8a (Ly 2) monoclonal antibody reacts with a protein of approximately 30 kD found on mouse thymocytes and mouse cytotoxic/ suppressor T cells. It does not bind to mouse helper/inducer T cells. It binds to T lymphocytes from all mouse strai.
The applications listed have been tested for the unmodified form of this product. Other forms have not been tested.
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain.