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Mouse CD71 / Transferrin Receptor | |
Rat | |
Mouse (tested or 100% immunogen sequence identity) | |
IgG2a Monoclonal [YTA74.4] | |
Unconjugated. Also available conjugated with FITC, RPE. | |
Protein G purified | |
Unmodified. Also available Low Endotoxin. |
Mouse Concanavalin A activated spleen cells. | |
Recognizes the mouse Transferrin receptor protein 1 also known as CD71 or TfR1. CD71 is a 763 amino acid glycoprotein homodimer of ~95 kD subunits. CD71 is expressed by dividing cells, and functions as a transferrin receptor mediating uptake of iron. Blocks the binding of R17 217.1.3. and R17 208.2 anti-TFR monoclonal antibodies. | |
Flow Cytometry: Use 10 ul of the suggested working dilution to label 1 x 10^6 cells in 100 ul. Method sheets are available on request. |
0.09% sodium azide. | |
Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles. | |
For research use only. |
TFRC Antibody, CD71 Antibody, TFR1 Antibody, TRFR Antibody, TFR Antibody, TR Antibody, CD71 antigen Antibody, p90 Antibody, T9 Antibody, Transferrin receptor Antibody, Transferrin receptor protein 1 Antibody
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system By similarity.