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Anti-CD59 Antibody (RPE) LS-C45293

Note: This antibody replaces LS-C58631

Ordering

Wt. Vol. Conc. Price
- 100 tst - $350
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular CD59 Antibodies

Anti-CD59 Antibody (Biotin) LS-C35698
Mouse Monoclonal (IgG1) to Human CD59
Human
Flow Cytometry
Biotin Conjugated
Anti-CD59 Antibody (clone MEM-43/5) IHC-plus™ LS-B1853
Mouse Monoclonal [clone MEM-43/5] (IgG2b) to Human CD59
Human, Mouse
IHC - Paraffin, Western blot, Immunoprecipitation, Flow Cytometry
Unconjugated
Immunohistochemistry Image
Anti-CD59 Antibody (clone p282(H19)) IHC-plus™ LS-B1960
Mouse Monoclonal [clone p282(H19)] (IgG2a,k) to Human CD59
Human, Baboon, Monkey
IHC - Paraffin, Flow Cytometry
Unconjugated
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed
Rat Monoclonal (IgG2b) to Human CD59
Human
IHC - Paraffin, IHC - Frozen, Western blot, Flow Cytometry (applications tested for the base form of this product only)
RPE Conjugated

Details

Human CD59
Rat
Human (tested or 100% immunogen sequence identity)
IgG2b Monoclonal
R. Phycoerythrin. Also available Unconjugated or conjugated with FITC.
Ion exchange chromatography
Unmodified

Applications

  • IHC - Paraffin
  • IHC - Frozen
  • Western blot
  • Flow Cytometry (1:1)
  • (applications tested for the base form of this product only)

Specificity and Use

CD59 antibody was raised against human peripheral blood T cells.
Clustered at the fourth leucocyte typing workshop to designation CD59(1). YTH53. Reacts with CD59 transfectants(3). It enhances antibody-mediated lysis by homologous complement(2) Reacts with GPI-linked antigen of 18-20kD size which is broadly expressed on human leucocytes and erythrocytes(2). Putative ligand for CD2.
The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested. Flow Cytometry: Use 10 ul of the suggested working dilution to label 10^6 cells in 100 ul. We do not recommend using this antibody in lysed whole blood techniques due to inhibition of staining caused by CD59 expression on erythrocytes.

Packaging

Lyophilized, PBS, pH 7.2, 0.09% sodium azide, 1% BSA.
100 tst Distilled Water.
For research use only.

About CD59

P13987 NM_000611 NP_000602.1

CD59 Antibody, 16.3A5 Antibody, 1F5 Antibody, 1F5 antigen Antibody, CD59 glycoprotein Antibody, EL32 Antibody, EJ16 Antibody, G344 Antibody, HRF-20 Antibody, MAC-IP Antibody, MACIF Antibody, Ly-6-like protein Antibody, MEM43 Antibody, MIRL Antibody, MEM43 antigen Antibody, MIN2 Antibody, MIN3 Antibody, MSK21 Antibody, p18-20 Antibody, Protectin Antibody, MAC-inhibitory protein Antibody, MIC11 Antibody, T cell-activating protein Antibody, CD59 antigen Antibody, EJ30 Antibody, HRF20 Antibody, Human leukocyte antigen MIC11 Antibody, Lymphocytic antigen CD59/MEM43 Antibody, MIN1 Antibody

CD59 is a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation.

Immunohistochemistry

Immunohistochemistry
Anti-CD59 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5245 concentration 10 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Immunohistochemistry

Immunohistochemistry
Anti-CD59 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5245 concentration 10 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Requested From: United States
Date Requested: 12/6/2016

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