Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Rat Monoclonal [clone YTH24.5] (IgG2b) to Human CD45 / LCA
IHC, IHC - Paraffin, Flow Cytometry
Mouse Monoclonal [clone MRC OX-30] (IgG2a) to Rat CD45 / LCA
IHC, IHC - Frozen, Flow Cytometry
Rat CD45 / LCA
Rat (tested or 100% immunogen sequence identity)
IgG2a Monoclonal [MRC OX-30]
Protein G purified
IHC - Frozen
Flow Cytometry (0.5 µg/10E6 cells)
Specificity and Use
CD45 / LCA antibody was raised against lymph node glycoproteins and cells.
Anti-rat CD45 (Leukocyte Common Antigen) monoclonal antibody recognizes a monomorphic determinant of the rat leukocyte common antigen. The antigen recognized is a heavily glycosylated membrane glycoprotein of molecular weight 170000 kD on thymocytes but.
The applications listed have been tested for the unmodified form of this product. Other forms have not been tested.
CD45 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP.