Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Rat Monoclonal [clone YTH24.5] (IgG2b) to Human CD45 / LCA
IHC - Paraffin, Flow Cytometry
Rat Monoclonal [clone IBL-5/25] (IgG1) to Mouse CD45 / LCA
Mouse CD45 / LCA
Mouse (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [IBL-5/25]
Flow Cytometry (2 µg/10E6 cells)
Specificity and Use
CD45 / LCA antibody was raised against iL-3 dependent mast cells derived from WB- +/+ mice.
Anti-mouse CD45 monoclonal antibody detects CD45 (L-CA) which is a trans- membrane phosphotyrosine phosphatase expressed on leukocytes. This mAb induces the in vitro clustering of mouse lymphocytes (both T and B cells)
The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.
CD45 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP.