Human, Bat, Bovine, Horse, Pig, Rabbit, Sheep
(tested or 100% immunogen sequence identity)
Dog (at least 90% immunogen sequence identity)
- IHC - Paraffin (0.5 - 1 µg/ml)
- Western blot (0.5 - 1 µg/ml)
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CD40L antibody was raised against synthetic peptide from the N-terminus of human CD40L (HRRLDKIEDERNLHEDFVF, aa47-65 of UniProt P29965). Percent identity by BLAST analysis: Human, Sheep, Bovine, Bat, Elephant, Rabbit, Horse, Pig (100%); Ferret, Cat, Dog (95%); Guinea pig (89%); Mouse (84%); Rat (79%).
CD40 ligand (CD40L) is a type II membrane protein of 261 amino acids on activated T cells that induces B cell proliferation and immunoglobulin secretion. It has homology with tumour necrosis factor-alpha and -beta, and has important functions in B-cell activation and differentiation. Human CD40L with 5 exons, is mapped to the proximal region of the mouse X chromosome on Xq26.3-27.1, and can be detected on T cells but is absent from B cells and monocytes. Since CD40L is expressed on platelets and released from them on activation, its predictive value as a marker for clinical outcome and the therapeutic effect of inhibition of glycoprotein IIb /IIIa receptor in patients with acute coronary syndromes was investigated. The soluble CD40L may be involved in the process of restenosis and that it exerts its effect by triggering a complex group of inflammatory reactions on endothelial and mononuclear cells. CD40L plays a central role in the pathophysiology of acute coronary syndromes, and has a role in the pathogenesis of coronary artery lesions.
Lyophilized from PBS, 2.5% BSA, 0.025% sodium azide/thimerosal.
0.2 ml Sterile distilled water
Prior to reconstitution, 4°C. Following reconstitution store at -20°C. Avoid freeze-thaw cycles.
For research use only.
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