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Anti-CD40L Antibody (aa47-65) LS-C388207

Catalog Size Price
LS-C388207-100 100 µg (0.5 mg/ml) Unavailable

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207 CD40L Antibodies

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100% Guaranteed
Rabbit Polyclonal (IgG) to Human CD40L
Human, Bat, Bovine, Horse, Pig, Rabbit, Sheep
IHC - Paraffin, Western blot
Unconjugated

Details

Human CD40L
Rabbit
Human, Bat, Bovine, Horse, Pig, Rabbit, Sheep (tested or 100% immunogen sequence identity)
Dog (at least 90% immunogen sequence identity)
IgG Polyclonal
Unconjugated
Immunoaffinity purified
Unmodified

Applications

  • IHC - Paraffin (0.5 - 1 µg/ml)
  • Western blot (0.5 - 1 µg/ml)

Specificity and Use

CD40L antibody was raised against synthetic peptide from the N-terminus of human CD40L (HRRLDKIEDERNLHEDFVF, aa47-65 of UniProt P29965). Percent identity by BLAST analysis: Human, Sheep, Bovine, Bat, Elephant, Rabbit, Horse, Pig (100%); Ferret, Cat, Dog (95%); Guinea pig (89%); Mouse (84%); Rat (79%).
aa47-65
Human CD40L
CD40 ligand (CD40L) is a type II membrane protein of 261 amino acids on activated T cells that induces B cell proliferation and immunoglobulin secretion. It has homology with tumour necrosis factor-alpha and -beta, and has important functions in B-cell activation and differentiation. Human CD40L with 5 exons, is mapped to the proximal region of the mouse X chromosome on Xq26.3-27.1, and can be detected on T cells but is absent from B cells and monocytes. Since CD40L is expressed on platelets and released from them on activation, its predictive value as a marker for clinical outcome and the therapeutic effect of inhibition of glycoprotein IIb /IIIa receptor in patients with acute coronary syndromes was investigated. The soluble CD40L may be involved in the process of restenosis and that it exerts its effect by triggering a complex group of inflammatory reactions on endothelial and mononuclear cells. CD40L plays a central role in the pathophysiology of acute coronary syndromes, and has a role in the pathogenesis of coronary artery lesions.

Packaging

Lyophilized from PBS, 2.5% BSA, 0.025% sodium azide/thimerosal.
0.2 ml Sterile distilled water
Prior to reconstitution, +4°C. Following reconstitution store at -20°C. Avoid freeze-thaw cycles.
For research use only.

About CD40L

P29965 NM_000074 NP_000065.1

CD40LG Antibody, CD154 Antibody, CD154 antigen Antibody, CD40-L Antibody, CD40 ligand Antibody, CD40L Antibody, gp39 Antibody, HIGM1 Antibody, IGM Antibody, IMD3 Antibody, T-BAM Antibody, TNFSF5 Antibody, CD40 antigen ligand Antibody, CD54 Antibody, HCD40L Antibody, T-B cell-activating molecule Antibody, T-cell antigen Gp39 Antibody, TNF-related activation protein Antibody

TNFSF5 is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in inability of immunoglobulin class switch and is associated with hyper IgM syndrome.

Immunohistochemistry

Immunohistochemistry
IHC-P: CD40L antibody testing of rat intestine tissue

Western blot

Western blot
Western blot testing of CD40L antibody and Lane 1: MCF-7; 2: HeLa; 3: Jurkat; 4: HMY2; 5: COLO320; Predicted size: 29KD; Observed size: 29KD

Requested From: 
Date Requested: 12/15/2017

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