LSBio
LSBio
Products
Services
Research Areas
Resources
Contact Us
Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121

Phone: 866-819-4732 (Toll Free North America)
206-374-1102 (International)

Fax: 866-206-6909 (Toll Free North America)
206-577-4565 (International)

How to Buy - Details about how to buy our products.

Orders@LSBio.com - To submit a new order.

Customer.Support@LSBio.com - To submit questions about existing orders, pricing, availability, bulk quotes, proforma invoice requests, or other billing issues.

Technical.Support@LSBio.com - To request technical information requests about an LSBio product or its application.

Sales@LSBio.com - To request information about fee-for-service contract IHC studies, IHC reports, distribution agreements, or general business development.

Worldwide Distributors List - To find your local distributor if you're not within the United States.
Products
Services
Research Areas
Resources
Contact Us
CD40L Antibody (aa47‑65) LS‑C388207
CD40L antibody LS-C388207 is an unconjugated rabbit polyclonal antibody to CD40L from human, bat, bovine and other species. Validated for IHC and WB.
Catalog
Size
Price
LS-C388207-100
100 µg (0.5 mg/ml)
$415

Popular CD40L Products

Antibody
Species: Human
Applications: IHC, IHC - Paraffin, Western blot
Antibody
Species: Human
Applications: IHC, Western blot, Flow Cytometry, ELISA, Functional Assay
Anti-CD40LG / CD54 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7421 concentration 5 ug/ml.
Species: Human
Applications: IHC, IHC - Paraffin, Western blot, ELISA
CD40LG monoclonal antibody (M01), clone 2E2 Western Blot analysis of CD40LG expression in K-562.
Species: Human
Applications: Western blot, ELISA
Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
Species: Human, Mouse, Rat
Applications: IHC, IHC - Paraffin, ICC, Western blot

Product Description

CD40L antibody LS-C388207 is an unconjugated rabbit polyclonal antibody to CD40L from human, bat, bovine and other species. Validated for IHC and WB.
About CD40L
TNFSF5 is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in inability of immunoglobulin class switch and is associated with hyper IgM syndrome. P29965 NM_000074 NP_000065.1

CD40LG Antibody, CD154 Antibody, CD154 antigen Antibody, CD40-L Antibody, CD40 ligand Antibody, CD40L Antibody, gp39 Antibody, HIGM1 Antibody, IGM Antibody, IMD3 Antibody, T-BAM Antibody, TNFSF5 Antibody, CD40 antigen ligand Antibody, CD54 Antibody, HCD40L Antibody, T-B cell-activating molecule Antibody, T-cell antigen Gp39 Antibody, TNF-related activation protein Antibody


Specifications

Target
Human CD40L
Host
Rabbit
Reactivity
Human, Bat, Bovine, Horse, Pig, Rabbit, Sheep (tested or 100% immunogen sequence identity)
Predicted
Dog (at least 90% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (0.5 - 1 µg/ml)
  • Western blot (0.5 - 1 µg/ml)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
CD40L antibody was raised against synthetic peptide from the N-terminus of human CD40L (HRRLDKIEDERNLHEDFVF, aa47-65 of UniProt P29965). Percent identity by BLAST analysis: Human, Sheep, Bovine, Bat, Elephant, Rabbit, Horse, Pig (100%); Ferret, Cat, Dog (95%); Guinea pig (89%); Mouse (84%); Rat (79%).
Epitope
aa47-65
Specificity
Human CD40L
Usage
CD40 ligand (CD40L) is a type II membrane protein of 261 amino acids on activated T cells that induces B cell proliferation and immunoglobulin secretion. It has homology with tumour necrosis factor-alpha and -beta, and has important functions in B-cell activation and differentiation. Human CD40L with 5 exons, is mapped to the proximal region of the mouse X chromosome on Xq26.3-27.1, and can be detected on T cells but is absent from B cells and monocytes. Since CD40L is expressed on platelets and released from them on activation, its predictive value as a marker for clinical outcome and the therapeutic effect of inhibition of glycoprotein IIb /IIIa receptor in patients with acute coronary syndromes was investigated. The soluble CD40L may be involved in the process of restenosis and that it exerts its effect by triggering a complex group of inflammatory reactions on endothelial and mononuclear cells. CD40L plays a central role in the pathophysiology of acute coronary syndromes, and has a role in the pathogenesis of coronary artery lesions.
Presentation
Lyophilized from PBS, 2.5% BSA, 0.025% sodium azide/thimerosal.
Reconstitution
0.2 ml Sterile distilled water
Storage
Prior to reconstitution, 4°C. Following reconstitution store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

Publications (0)


Customer Reviews (0)


Images

Immunohistochemistry

IHC-P: CD40L antibody testing of rat intestine tissue
IHC-P: CD40L antibody testing of rat intestine tissue

Western blot

Western blot testing of CD40L antibody and Lane 1: MCF-7; 2: HeLa; 3: Jurkat; 4: HMY2; 5: COLO320; Predicted size: 29KD; Observed size: 29KD
Western blot testing of CD40L antibody and Lane 1: MCF-7; 2: HeLa; 3: Jurkat; 4: HMY2; 5: COLO320; Predicted size: 29KD; Observed size: 29KD

Immunohistochemistry

IHC-P: CD40L antibody testing of rat intestine tissue
IHC-P: CD40L antibody testing of rat intestine tissue

Western blot

Western blot testing of CD40L antibody and Lane 1: MCF-7; 2: HeLa; 3: Jurkat; 4: HMY2; 5: COLO320; Predicted size: 29KD; Observed size: 29KD
Western blot testing of CD40L antibody and Lane 1: MCF-7; 2: HeLa; 3: Jurkat; 4: HMY2; 5: COLO320; Predicted size: 29KD; Observed size: 29KD

Immunohistochemistry

IHC-P: CD40L antibody testing of rat intestine tissue
IHC-P: CD40L antibody testing of rat intestine tissue

Western blot

Western blot testing of CD40L antibody and Lane 1: MCF-7; 2: HeLa; 3: Jurkat; 4: HMY2; 5: COLO320; Predicted size: 29KD; Observed size: 29KD
Western blot testing of CD40L antibody and Lane 1: MCF-7; 2: HeLa; 3: Jurkat; 4: HMY2; 5: COLO320; Predicted size: 29KD; Observed size: 29KD

Immunohistochemistry

IHC-P: CD40L antibody testing of rat intestine tissue
IHC-P: CD40L antibody testing of rat intestine tissue

Western blot

Western blot testing of CD40L antibody and Lane 1: MCF-7; 2: HeLa; 3: Jurkat; 4: HMY2; 5: COLO320; Predicted size: 29KD; Observed size: 29KD
Western blot testing of CD40L antibody and Lane 1: MCF-7; 2: HeLa; 3: Jurkat; 4: HMY2; 5: COLO320; Predicted size: 29KD; Observed size: 29KD

Requested From: United States
Date Requested: 7/21/2018

Get Social With Us! Follow us on Facebook Follow us on Google+ Follow us on LinkedIn PSL Alliance Member
Copyright © 2018 LifeSpan BioSciences, Inc. All Rights Reserved Privacy Policy



Catalog Number