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Anti-CD276 / B7-H3 Antibody (aa1-242, clone MJ18, Low Endotoxin) LS-C188633

Ordering

Wt. Vol. Conc. Price
500 µg - 1 mg/ml $450
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular CD276 / B7-H3 Antibodies

Anti-CD276 / B7-H3 Antibody (clone MIH42) IHC-plus™ LS-B2614
Mouse Monoclonal [clone MIH42] (IgG1) to Human CD276 / B7-H3
Human
IHC - Paraffin, IHC - Frozen, Flow Cytometry
Unconjugated
Immunohistochemistry Image
Anti-CD276 / B7-H3 Antibody (clone 6A1) LS-C169253
Mouse Monoclonal [clone 6A1] (IgG1) to Human CD276 / B7-H3
Human
IHC - Paraffin, Western blot, Flow Cytometry, ELISA
Unconjugated
Immunohistochemistry Image
Anti-CD276 / B7-H3 Antibody (clone SP206) LS-C210430
Rabbit Monoclonal [clone SP206] (IgG) to Human CD276 / B7-H3
Human
IHC - Paraffin, Western blot, Flow Cytometry
Unconjugated
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed
Rat Monoclonal [clone MJ18] (IgG1) to Mouse CD276 / B7-H3
Mouse
Flow Cytometry, Functional Assay
Unconjugated, Low Endotoxin

Details

Mouse CD276 / B7-H3
Rat
Mouse (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [MJ18]
Unconjugated
Protein G purified
Low Endotoxin

Applications

  • Flow Cytometry (1:25 - 1:200)
  • Functional Assay

Specificity and Use

CD276 / B7-H3 antibody was raised against mouse IgG2a Fc-CD276 (aa 1-242).
aa1-242
Recognizes mouse CD276, otherwise known as B7-H3, a ubiquitously expressed transmembrane glycoprotein and member of the B7 family of co-stimulatory molecules, which acts as both a positive and negative regulator of T-cell-mediated immune responses. CD276 is highly expressed in bone during embryogenesis, and can be induced on dendritic cells and monocytes by inflammatory cytokines. CD276 has been implicated in the development of acute and chronic transplant rejection, and is reported to have therapeutic potential as a regulator of cell-mediated immune responses to cancer, particularly in conjunction with anti-angiogenic therapy. In mice, CD276 has been linked with the development of pathogenic Th2 cells during the induction phase of allergic asthma. Studies have shown that clone MJ18 inhibits stimulated CD4+ T-cell proliferation.
The applications listed have been tested for the unmodified form of this product. Other forms have not been tested.

Packaging

PBS
Store at -20°C. Minimize freezing and thawing.
For research use only.

About CD276 / B7-H3

Q5ZPR3 NM_025240 NP_079516.1

CD276 Antibody, 4Ig-B7-H3 Antibody, B7 homolog 3 Antibody, B7-H3 Antibody, CD276 antigen Antibody, CD276 molecule Antibody, Costimulatory molecule Antibody, B7H3 Antibody, B7RP-2 Antibody

May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy.

Requested From: United States
Date Requested: 12/4/2016

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