Human CD209 / DC-SIGN

Rabbit

Human, Mouse (tested or 100% immunogen sequence identity)

IgG Polyclonal

Unconjugated

Protein A purified

Unmodified

A recombinant protein fragment from human DC-SIGN.

Human CD209 / DC-SIGN

• Western blot (2 - 5 µg/ml)

DC-SIGN (Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin) also known as CD209, is part of the Lectin family of proteins. DC-SIGN is part of the innate immune response via its modulation of Toll-like Receptors. It is present on the surface of macrophages and dendritic cells and binds mannose carbohydrates, a class of PAMPS found on bacteria, fungi and viruses. PAMP stimulated DC-SIGN activates the Raf kinases Raf-1 and B-Raf. Raf-1 phosphorylates Ser276 of NF-kB p65 which serves as a binding site for histone acetyltransferases CREB-binding protein (CBP) and p300. Acetylation of NF-kB p65 leads to enhanced and prolonged anti-inflammatory cytokine IL-10 production.

1X PBS, pH 7.4, 0.1 mg/ml BSA, 0.05% Sodium Azide

Store at -20°C. Avoid freeze-thaw cycles.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: Q9NNX6 NCBI: NM_021155 NP_066978.1