Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone O10] (IgG1,k) to Human CD1A
IHC - Paraffin
Mouse Monoclonal (IgG1) to Human CD1A
Human (tested or 100% immunogen sequence identity)
Protein G purified
Specificity and Use
Recognizes a 49kD polypeptide associated with b2-microglobulin (b2m) expressed on cortical thymocytes (strongly), Langerhans cells, dendritic cells, some T cell leukemias and lymphomas. Does not react with peripheral blood T and B lymphocytes, monocytes, granulocytes, platelets and erythrocytes.
Suitable for use in Flow Cytometric analysis using 100 ul peripheral blood cells or 20 ul/1E6 cells. The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.
PBS, pH 7.2, 0.1% sodium azide.
Short term: +4°C; Long term: Add glycerol (40-50%) -20°C.
CD1A is a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1.