Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [AE1]
IHC - Frozen (1:50 - 1:200)
Specificity and Use
The antigen is CD19. The epitope has not been further characterized. Antigen distribution: Isolated cells: 5-50% of human peripheral blood mononuclear cells. Tissue sections: The antigen is expressed on B-cells and follicular dendritic cells. Specificity: Human: CD19 Other: not tested.
Lyophilized from PBS pH 7.2, 5mg/ml BSA, 0.09% sodium azide
Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.