Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone 4C4] (IgG2a,k) to Human CD177
IHC, IHC - Paraffin, Western blot, Immunoprecipitation, ELISA
Mouse Monoclonal (IgG1) to Human CD177
Human, Monkey (tested or 100% immunogen sequence identity)
Protein G purified
Specificity and Use
CD177 antibody was raised against human CD177.
Recognizes human CD177 (neutrophil glycoprotein NB1).
Suitable for use in Flow Cytometry. Flow Cytometry: Neat; Use 10 ul to label 1E6 cells in 100ul. The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.
CD177 encodes a glycosyl-phosphatidylinositol (GPI)-linked cell surface glycoprotein that plays a role in neutrophil activation. The protein can bind platelet endothelial cell adhesion molecule-1 and function in neutrophil transmigration. Mutations in this gene are associated with myeloproliferative diseases. Over-expression of this gene has been found in patients with polycythemia rubra vera.