Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
IHC, IHC - Paraffin, ICC, Flow Cytometry, ELISA, Functional Assay (applications tested for the base form of this product only)
Human, Primate (tested or 100% immunogen sequence identity)
Also available conjugated with Biotin, DY550.
IHC - Paraffin
Flow Cytometry (25 µg/ml)
ELISA (1 µg/ml)
(applications tested for the base form of this product only)
Specificity and Use
CCR5 antibody was raised against a synthetic peptide demonstrating a high affinity towards the monoclonal CCR5 2D7 (see reference 2). This peptide is known as the 2D7-2SK peptide and consists of the following residues: EWQKEGLVTLWLGGGGSC.
the linear epitope detected by the monoclonal antibody 2D7.
The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.
CCR5 is a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance.
Anti-CCR5 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B275 concentration 5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
CCR5 Antibody - CCR5 antibody was tested in HeLa cells with FITC (green). Nuclei and alpha-tubulin were counterstained with Dapi (blue) and Dylight 594 (red). This image was taken for the unconjugated form of this product. Other forms have not been tested.