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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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CCR4 Antibody (Extracellular Domain) IHC‑plus™ LS‑B4033
Note: This antibody replaces LS-C83946
CCR4 antibody LS-B4033 is an unconjugated goat polyclonal antibody to CCR4 from human and monkey. Validated for ELISA, Flow, IHC and WB. Tested on 20 paraffin-embedded human tissues.
Catalog
Size
Price
LS-B4033-50
50 µg (1 mg/ml)
Unavailable

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Product Description

CCR4 antibody LS-B4033 is an unconjugated goat polyclonal antibody to CCR4 from human and monkey. Validated for ELISA, Flow, IHC and WB. Tested on 20 paraffin-embedded human tissues.
About CCR4
High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival. P51679 NM_005508 NP_005499.1

CCR4 Antibody, C-C chemokine receptor type 4 Antibody, CD194 Antibody, CD194 antigen Antibody, C-C CKR-4 Antibody, Chemr13 Antibody, CKR-4 Antibody, CC chemokine receptor 4 Antibody, CC-CKR-4 Antibody, CCR-4 Antibody, HGCN:14099 Antibody, C-c chemokine receptor 4 Antibody, Chemokine (C-C) receptor 4 Antibody, CKR4 Antibody, CMKBR4 Antibody, K5-5 Antibody


Specifications

Target
Human CCR4
Host
Goat
Reactivity
Human, Monkey (tested or 100% immunogen sequence identity)
Predicted
Dog, Hamster, Horse (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (5 µg/ml)
  • Western blot (1:500)
  • Flow Cytometry (1:12)
  • ELISA (1:30000)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
CCR4 antibody was raised against 17SNYYLYESIPKPCTKEGIKAFGE39 corresponding to human CCR4 extracellular domain. Percent identity by BLAST analysis: Human, Gorilla, Monkey, Marmoset (100%); Gibbon, Panda (96%); Hamster, Dog, Horse (91%); Elephant, Rabbit (87%); Mouse (83%).
Epitope
Extracellular Domain
Specificity
Peptide sequence is <50% identical to other chemokine receptors in this region.
Usage
Immunohistochemistry: LS-B4033 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B4033 was determined to be 5 ug/ml.
Presentation
10 mM KHPO4, 140 mM NaCl with 1 mg/ml BSA and 0.1% sodium azide
Storage
Short term: -20°C; Long term: -70°C; Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Images


Immunohistochemistry

Anti-CCR4 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4033 concentration 5 ug/ml.
Anti-CCR4 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4033 concentration 5 ug/ml.

Immunohistochemistry

Anti-CCR4 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4033 concentration 5 ug/ml.
Anti-CCR4 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4033 concentration 5 ug/ml.

Immunohistochemistry

Anti-CCR4 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4033 concentration 5 ug/ml.
Anti-CCR4 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4033 concentration 5 ug/ml.

Immunohistochemistry

Anti-CCR4 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4033 concentration 5 ug/ml.
Anti-CCR4 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4033 concentration 5 ug/ml.

Immunohistochemistry

Anti-CCR4 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4033 concentration 5 ug/ml.
Anti-CCR4 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4033 concentration 5 ug/ml.

Immunohistochemistry

Anti-CCR4 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4033 concentration 5 ug/ml.
Anti-CCR4 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4033 concentration 5 ug/ml.

Immunohistochemistry

Anti-CCR4 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4033 concentration 5 ug/ml.
Anti-CCR4 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4033 concentration 5 ug/ml.

Immunohistochemistry

Anti-CCR4 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4033 concentration 5 ug/ml.
Anti-CCR4 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4033 concentration 5 ug/ml.


Requested From: 
Date Requested: 6/21/2018

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