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Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene.
Gene Name: | Chibby Homolog 1 |
Synonyms: | CBY1, Arb1, C22orf2, Chibby, HS508I15A, PGEA1, PIGEA-14, Protein chibby homolog 1, PIGEA14, ARPP-binding protein, CBY, Chibby homolog 1 (Drosophila), Coiled-coil protein PIGEA-14, Cytosolic leucine-rich protein |
Target Sequences: | NM_015373 NP_056188.1 |
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