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CBLL1 / HAKAI is an E3 ubiquitin-ligase for the E-cadherin complex and mediates its ubiquitination, endocytosis, and degradation in the lysosomes. The encoded protein contains a RING-finger domain and is also thought to have a role in control of cell proliferation. A related pseudogene has been identified on chromosome X. Alternative splicing results in a non-coding transcript variant.
Gene Name: | Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase |
Synonyms: | CBLL1, C-Cbl-like protein 1, E-cadherin binding protein E7, HAKAI, RING finger protein 188, RNF188 |
Target Sequences: | NM_024814 NP_079090.2 Q75N03 |
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