LSBio
LSBio
Products
Services
Research Areas
Resources
Contact Us
Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121

Phone: 866-819-4732 (Toll Free North America)
206-374-1102 (International)

Fax: 866-206-6909 (Toll Free North America)
206-577-4565 (International)

How to Buy - Details about how to buy our products.

Orders@LSBio.com - To submit a new order.

Customer.Support@LSBio.com - To submit questions about existing orders, pricing, availability, bulk quotes, proforma invoice requests, or other billing issues.

Technical.Support@LSBio.com - To request technical information requests about an LSBio product or its application.

Sales@LSBio.com - To request information about fee-for-service contract IHC studies, IHC reports, distribution agreements, or general business development.

Worldwide Distributors List - To find your local distributor if you're not within the United States.
Products
Services
Research Areas
Resources
Contact Us
c‑CBL Antibody (Ser668) LS‑C176316
C-CBL antibody LS-C176316 is an unconjugated rabbit polyclonal antibody to c-CBL from human, mouse and rat. Validated for IHC and WB.
Catalog
Size
Price
LS-C176316-100
100 µl
Unavailable

Popular c-CBL Products

Staining (2?g/ml) of 3T3 lysate (RIPA buffer, 35?g total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
Species: Human, Monkey, Mouse, Bovine, Dog, Hamster, Horse, Pig, Rabbit, Chicken
Applications: Western blot, Peptide Enzyme-Linked Immunosorbent Assay
Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
Species: Human, Mouse, Rat
Applications: IHC, IHC - Paraffin, Immunofluorescence, Western blot, Flow Cytometry, ELISA
Immunohistochemical analysis of c-CBL (pY774) staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Species: Human, Mouse, Rat
Applications: IHC, IHC - Paraffin, ICC, Immunofluorescence, Western blot
Immunohistochemical analysis of c-CBL (pY700) staining in human lymph node formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP-conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Species: Human, Mouse, Rat
Applications: IHC, IHC - Paraffin, ICC, Immunofluorescence, Western blot
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA004578LA01HU at dilution of 1:100
Species: Human
Applications: IHC, Immunofluorescence, Western blot, ELISA

Product Description

C-CBL antibody LS-C176316 is an unconjugated rabbit polyclonal antibody to c-CBL from human, mouse and rat. Validated for IHC and WB.
About c-CBL
Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling. P22681 NM_005188 NP_005179.2

CBL Antibody, C-CBL Antibody, Oncogene CBL2 Antibody, RING finger protein 55 Antibody, Proto-oncogene c-Cbl Antibody, RNF55 Antibody, CBL2 Antibody, FRA11B Antibody, NSLL Antibody


Specifications

Target
Human c-CBL
Host
Rabbit
Reactivity
Human, Mouse, Rat (tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin
  • Western blot
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
c-CBL antibody was raised against synthetic peptide around Ser668 of human CBL
Epitope
Ser668
Specificity
Human CBL
Presentation
PBS, pH 7.2, 0.05% sodium azide
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

Publications (0)


Customer Reviews (0)


Images


Immunohistochemistry

IHC of CBL (S668) pAb in paraffin-embedded human colon carcinoma tissue.
IHC of CBL (S668) pAb in paraffin-embedded human colon carcinoma tissue.

Western blot

Western blot of CBL (S668) pAb in extracts from HepG2 cells treated with Na2VO3 0.3nM 40'.
Western blot of CBL (S668) pAb in extracts from HepG2 cells treated with Na2VO3 0.3nM 40'.

Immunohistochemistry

IHC of CBL (S668) pAb in paraffin-embedded human colon carcinoma tissue.
IHC of CBL (S668) pAb in paraffin-embedded human colon carcinoma tissue.

Western blot

Western blot of CBL (S668) pAb in extracts from HepG2 cells treated with Na2VO3 0.3nM 40'.
Western blot of CBL (S668) pAb in extracts from HepG2 cells treated with Na2VO3 0.3nM 40'.

Immunohistochemistry

IHC of CBL (S668) pAb in paraffin-embedded human colon carcinoma tissue.
IHC of CBL (S668) pAb in paraffin-embedded human colon carcinoma tissue.

Western blot

Western blot of CBL (S668) pAb in extracts from HepG2 cells treated with Na2VO3 0.3nM 40'.
Western blot of CBL (S668) pAb in extracts from HepG2 cells treated with Na2VO3 0.3nM 40'.

Immunohistochemistry

IHC of CBL (S668) pAb in paraffin-embedded human colon carcinoma tissue.
IHC of CBL (S668) pAb in paraffin-embedded human colon carcinoma tissue.

Western blot

Western blot of CBL (S668) pAb in extracts from HepG2 cells treated with Na2VO3 0.3nM 40'.
Western blot of CBL (S668) pAb in extracts from HepG2 cells treated with Na2VO3 0.3nM 40'.


Requested From: 
Date Requested: 6/24/2018

Get Social With Us! Follow us on Facebook Follow us on Google+ Follow us on LinkedIn PSL Alliance Member
Copyright © 2018 LifeSpan BioSciences, Inc. All Rights Reserved Privacy Policy



Catalog Number