Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal (IgG1) to Clostridium botulinum Botulinum Neurotoxin Type A
Clostridium botulinum, Clostridium
Mouse Monoclonal [clone 8365M] (IgG) to Clostridium botulinum Botulinum Neurotoxin Type A
Immunofluorescence, ELISA, Radioimmunoassay
Clostridium botulinum Botulinum Neurotoxin Type A
Clostridium botulinum (tested or 100% immunogen sequence identity)
IgG Monoclonal [8365M]
Tissue culture supernatant
Specificity and Use
Synthetic peptide analogue of the carboxyl terminal region of C. botulinum Toxin A.
Recognizes and binds to intact whole C. botulinum Toxin A, amino acids 1280-1292. Has been found to stain Neuro2A cells treated with GT1b ganglioside prior to the addition of C. botulinum Toxin A. Inhibits the entry of C. botulinum Toxin A to Neuro2A cells treated with GT1b ganglioside prior to the addition of the toxin. Cross-reactivity: C. botulinum Toxin A (1280-1292) and C. botulinum Toxin A: 100%, C. botulinum Toxin B, C, E and F (1272-1280): 0%.
Suitable for use in ELISA, Immunofluorescence and RIA. Immunocytochemistry1:50. Note: Prior incubation of the antibody with synthetic peptide immunogen has been shown to eliminate the inhibition of cellular binding by the antibody.
No preservatives added.
Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.