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BMPER is a secreted protein that interacts with, and inhibits bone morphogenetic protein (BMP) function. It has been shown to inhibit BMP2- and BMP4-dependent osteoblast differentiation and BMP-dependent differentiation of the chondrogenic cells. Mutations in this gene are associated with a lethal skeletal disorder, diaphanospondylodysostosis.
Gene Name: | BMP binding endothelial regulator |
Synonyms: | BMPER, CRIM3, Crossveinless 2, CV-2, Crossveinless-2, HCV2, Protein crossveinless-2, CV2, KIAA1965 |
Target Sequences: | NP_597725.1 Q8N8U9 |
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