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Anti-BMP7 Antibody LS-C43127

Ordering

Wt. Vol. Conc. Price
50 µg - 1 mg/ml $345
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
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Most Popular BMP7 Antibodies

Anti-BMP7 Antibody (aa165-214) IHC-plus™ LS-B4567
Rabbit Polyclonal to Rat BMP7
Rat, Human, Monkey, Mouse, Guinea pig
IHC - Paraffin, Western blot
Unconjugated
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed
Rabbit Polyclonal (IgG) to Human BMP7
Human
Western blot, ELISA
Unconjugated

Details

Human BMP7
Rabbit
Human (tested or 100% immunogen sequence identity)
IgG Polyclonal
Unconjugated
Purified
Unmodified

Applications

  • Western blot (0.1 - 0.2 µg/ml)
  • ELISA (0.5 µg/ml)

Specificity and Use

BMP7 antibody was raised against recombinant human BMP-7.
Recognizes the disulphide-linked homodimeric cysteine knot protein known as human Bone Morphogenetic Protein 7 (BMP-7) or Osteogenic protein 1 (OP-1). BMP-7 is a member of the transforming growth factor beta (TGF-B) superfamily and one of a growing number of osteogenic proteins shown to induce bone and cartilage formation, and to play an important role in developmental processes, including cell proliferation, differentiation, apoptosis and morphogenesis. BMPs act through binding with a receptor complex consisting of type I and type II serine/threonine kinases, resulting ultimately in the activation of the Smad protein and mitogen-activated protein kinase (MAPK) signaling pathways. Several antagonist proteins, including, noggin, chordin, gremlin and follistatin, are responsible for modulating the signaling effects of BMPs, through the binding and blocking of receptor ligands, thereby preventing activation. Studies into the properties of BMP-7 have largely focused on its role during ontogeny of the kidney, owing to its prominent expression in the renal tubules. Results from research into experimental diabetic nephropathy have indicated that BMP-7 has antifibrogenic properties and appears to act as an antagonist to TGF-Beta (3-4).
ELISA: May be used in an indirect ELISA or as the capture reagent in a sandwich ELISA.

Packaging

PBS, pH 7.4, 0.09% sodium azide.
For research use only.

About BMP7

P18075 NM_001719 NP_001710.1

BMP7 Antibody, Bone morphogenetic protein 7 Antibody, Eptotermin alfa Antibody, OP-1 Antibody, OP1 Antibody, Osteogenic protein 1 Antibody, BMP-7 Antibody

The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site.

Requested From: United States
Date Requested: 12/2/2016

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