Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human (tested or 100% immunogen sequence identity)
Western blot (0.1 - 0.2 µg/ml)
ELISA (0.5 - 1 µg/ml)
Specificity and Use
BMP10 antibody was raised against nS0-derived recombinant human Bone Morphogenetic Protein 10 Propeptide (aa20-313) Accession # O95393).
Recognizes human BMP-10.
Suitable for use in ELISA and Western Blot. ELISA: 0.5-1 ug/ml. Detection limit for rhBMP-10 is ~0.2 ng/ml. Western Blot: 0.1-0.2 ug/ml. Detection limit for rhBMP-10 is ~1 ng/ml under non-reducing and reducing conditions.
BMP10 Antibody, BMP-10 Antibody, Bone morphogenetic protein 10 Antibody
Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth.