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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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BMI1 / PCGF4 Antibody (clone 229F6) LS‑C150548
Note: This antibody replaces LS-C150549
Antibody
PCGF4 antibody LS-C150548 is an unconjugated mouse-balb/c monoclonal antibody to PCGF4 (BMI1) from human, mouse and rabbit. Validated for IHC, IP and WB.
Catalog
Size
Price
LS-C150548-100
100 µg (1 mg/ml)
Unavailable

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Product Description

PCGF4 antibody LS-C150548 is an unconjugated mouse-balb/c monoclonal antibody to PCGF4 (BMI1) from human, mouse and rabbit. Validated for IHC, IP and WB.
About BMI1 / PCGF4
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. P35226 NM_005180 NP_005171.4

BMI1 Antibody, BMI-1 Antibody, Flvi-2/bmi-1 Antibody, FLVI2/BMI1 Antibody, PCGF4 Antibody, Polycomb group protein Bmi1 Antibody, Polycomb complex protein BMI-1 Antibody, Dna-binding protein bmi-1 Antibody, Polycomb group ring finger 4 Antibody, RING finger protein 51 Antibody, RNF51 Antibody


Specifications

Target
BMI1 / PCGF4
Host
Mouse-Balb/c
Reactivity
Human, Mouse, Rabbit (tested or 100% immunogen sequence identity)
Clonality
IgG1 Monoclonal [229F6]
Conjugations
Unconjugated
Purification
Purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Frozen
  • Western blot
  • Immunoprecipitation
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
BMI1 / PCGF4 antibody was raised against recombinant Bmi1 protein corresponding to residues 1-202 of mouse Bmi-1 acterial fusion protein of membrane proximal non repeat domain of human episialin
Specificity
preferentially associates with several distinct heterochromatic domains in tumor cell lines.In both primary and tumor cell lines a marked cell cycleregulation of Pc-G-chromatin interaction isobserved.
Presentation
PBS containing 0.09% sodium azide
Storage
Short term 4°C, long term aliquot and store at -20°C, avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Requested From: 
Date Requested: 6/25/2018

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