Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human (tested or 100% immunogen sequence identity)
Western blot (1:500 - 1:3000)
Specificity and Use
Betaglycan / TGFBR3 antibody was raised against recombinant fragment corresponding to a region within amino acids 88 and 314 of TGF beta Receptor III (SwissProt Q03167). Percent identity by BLAST analysis: Human (100%); Pig (89%); Mouse (87%).
TGFBR3 Antibody, Betaglycan Antibody, BGCAN Antibody, TGF-beta receptor type 3 Antibody, TGF-beta receptor type III Antibody, TGFR-3 Antibody, Betaglycan proteoglycan Antibody, Tgf-beta receptors type iii Antibody
This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.