Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Hamster Monoclonal [clone Ham151-149] (IgG) to Mouse BCL2L11 / BIM
Mouse BCL2L11 / BIM
Mouse (tested or 100% immunogen sequence identity)
IgG Monoclonal [Ham151-149]
Specificity and Use
BCL2L11 / BIM antibody was raised against mouse BCL2L11
This Ham151-149 antibody has been tested by immunoblot analysis of mouse splenocytes. This can be used at approximately 1-5 ug/ml. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.
Aqueous buffer, 0.09% sodium azide, contains stabilizer if necessary
BCL2L11 / BIM belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator.
Lysates prepared from mouse splenocytes under reducing conditions were resolved by SDS-PAGE then immunoblotted with 2 ug/ml of anti-mouse Bim (Ham151-149) antibody. Bands were visualized using HRP-conjugated anti-Armenian hamster IgG.