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BCL2L10 / Diva belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASPASE 9 related apoptotic pathway.
Gene Name: | BCL2-like 10 (apoptosis facilitator) |
Family/Subfamily: | Apoptosis |
Synonyms: | BCL2L10, BCL-B, Apoptosis regulator Bcl-B, BCLB, Bcl2-L-10, Diva not vaccine, Anti-apoptotic protein NrH, Bcl-2-like protein 10, Boo, Boo not bladder, Diva |
Target Sequences: | NM_020396 NP_065129.1 Q9HD36 |
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