Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
(applications tested for the base form of this product only)
Specificity and Use
BCAM / CD239 antibody was raised against synthetic peptide located between aa459-508 of human BCAM (P50895, NP_005572). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla (100%); Monkey, Marmoset, Dog, Rabbit (85%); Horse (84%); Mouse, Rat (78%).
The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.
Short term, +4°C. Long term, add glycerol to 40-50%, aliquot to avoid freeze/thaw cycles, and store at -20°C. Sensitive to light.
BCAM / CD239 is Lutheran blood group glycoprotein, a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. The protein contains five extracellular immunoglobulin domains, a single transmembrane domain, and a short C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease.