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BABP / AKR1C2 is a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding two different isoforms have been found for this gene.
Gene Name: | aldo-keto reductase family 1, member C2 |
Synonyms: | AKR1C2, 3-alpha-HSD3, AKR1C-pseudo, BABP, Dihydrodiol dehydrogenase 2, DD-2, MCDR2, HAKRD, DD, DD2, DDH2, HBAB, Pseudo-chlordecone reductase, SRXY8 |
Target Sequences: | NP_995317.1 P52895 |
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