Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human (tested or 100% immunogen sequence identity)
IHC - Frozen (1:250 - 1:1000)
Specificity and Use
AURKA / Aurora-A antibody was raised against synthetic peptide corresponding to a region of human Aurora A Kinase encoded within exon 5.
Human aurora A kinase, also known as Serine/Threonine Kinase 6, STK6, Breast tumor-amplified kinase, ARK-1, Serine/threonine-protein kinase 15 or Aurora/IPL1-related kinase 1. Aurora A kinase is a cell-cycle regulated kinase that has an important role in centrosome maturation and chromosome segregation. This protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. Aurora A kinase is frequently overexpressed in various human carcinomas, which would suggest that this protein may be involved in tumorigenesis (Bischoff et al. 1998).
Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes.