The Immunohistochemistry Antibody Company
|Human, Mouse (tested or 100% immunogen sequence identity)|
|ATR antibody was raised against a synthetic peptide, which represented a portion of human Ataxia and Rad3-related kinase encoded within exon 5 (LocusLink ID 545).|
|Specific for human ATR protein. Species cross-reactivity: mouse. Other species have not been tested. The peptide used as the immunogen for this antibody is not conserved in Xenopus laevis (18 out 20 amino acids).|
|Suitable for use in Western Blot. Positive control: HeLa and U2OS whole cell lysates.|
|Tris-citrate/phosphate buffer, pH 7-8.|
|For research use only.|
ATR Antibody, FRAP-related protein-1 Antibody, FCTCS Antibody, SCKL1 Antibody, MEC1 Antibody, Protein kinase ATR Antibody, Rad3 related protein Antibody, SCKL Antibody, FRAP-related protein 1 Antibody, FRP1 AntibodySerine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis.