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Anti-ATR Antibody LS-C74416

Ordering

Wt. Vol. Conc. Price
100 µg - - $545
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
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Related Products

Most Popular ATR Antibodies

Anti-ATR Antibody (clone 1E9) IHC-plus™ LS-B4288
Mouse Monoclonal [clone 1E9] (IgG1,k) to Human ATR
Human
IHC - Paraffin, ELISA
Unconjugated
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed
Rabbit Polyclonal to Human ATR
Human, Mouse
Western blot
Unconjugated

Details

Human ATR
Rabbit
Human, Mouse (tested or 100% immunogen sequence identity)
Polyclonal
Unconjugated
Immunoaffinity purified
Unmodified

Applications

Western blot

Specificity and Use

ATR antibody was raised against a synthetic peptide, which represented a portion of human Ataxia and Rad3-related kinase encoded within exon 5 (LocusLink ID 545).
Specific for human ATR protein. Species cross-reactivity: mouse. Other species have not been tested. The peptide used as the immunogen for this antibody is not conserved in Xenopus laevis (18 out 20 amino acids).
Suitable for use in Western Blot. Positive control: HeLa and U2OS whole cell lysates.

Packaging

Tris-citrate/phosphate buffer, pH 7-8.
For research use only.

About ATR

Q13535 NM_001184 NP_001175.2

ATR Antibody, FRAP-related protein-1 Antibody, FCTCS Antibody, SCKL1 Antibody, MEC1 Antibody, Protein kinase ATR Antibody, Rad3 related protein Antibody, SCKL Antibody, FRAP-related protein 1 Antibody, FRP1 Antibody

Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis.

Requested From: United States
Date Requested: 12/7/2016

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