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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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ATR Antibody (phospho‑Ser428) LS‑C198655
ATR antibody LS-C198655 is an unconjugated rabbit polyclonal antibody to human ATR. Validated for IHC and Peptide-ELISA.
Catalog
Size
Price
LS-C198655-50
50 µl
Unavailable
LS-C198655-100
100 µl
Unavailable

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Product Description

ATR antibody LS-C198655 is an unconjugated rabbit polyclonal antibody to human ATR. Validated for IHC and Peptide-ELISA.
About ATR
Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Q13535 NM_001184 NP_001175.2

ATR Antibody, FRAP-related protein-1 Antibody, FCTCS Antibody, SCKL1 Antibody, MEC1 Antibody, Protein kinase ATR Antibody, Rad3 related protein Antibody, SCKL Antibody, FRAP-related protein 1 Antibody, FRP1 Antibody


Specifications

Target
Human ATR
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (1:50 - 1:100)
  • Peptide Enzyme-Linked Immunosorbent Assay (1:40000)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
ATR antibody was raised against synthetic peptide derived from human ATR around the phosphorylation site of Ser428.
Epitope
pSer428
Specificity
ATR (Phospho-Ser428) Antibody detects endogenous levels of ATR only when phosphorylated at serine428.
Presentation
PBS, pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
Storage
Store at -20°C.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Images


Immunohistochemistry

IHC of paraffin-embedded human colon carcinoma, using ATR (Phospho-Ser428) Antibody. The sample on the right was incubated with synthetic peptide.
IHC of paraffin-embedded human colon carcinoma, using ATR (Phospho-Ser428) Antibody. The sample on the right was incubated with synthetic peptide.

Immunohistochemistry

IHC of paraffin-embedded human colon carcinoma, using ATR (Phospho-Ser428) Antibody. The sample on the right was incubated with synthetic peptide.
IHC of paraffin-embedded human colon carcinoma, using ATR (Phospho-Ser428) Antibody. The sample on the right was incubated with synthetic peptide.

Immunohistochemistry

IHC of paraffin-embedded human colon carcinoma, using ATR (Phospho-Ser428) Antibody. The sample on the right was incubated with synthetic peptide.
IHC of paraffin-embedded human colon carcinoma, using ATR (Phospho-Ser428) Antibody. The sample on the right was incubated with synthetic peptide.

Immunohistochemistry

IHC of paraffin-embedded human colon carcinoma, using ATR (Phospho-Ser428) Antibody. The sample on the right was incubated with synthetic peptide.
IHC of paraffin-embedded human colon carcinoma, using ATR (Phospho-Ser428) Antibody. The sample on the right was incubated with synthetic peptide.


Requested From: 
Date Requested: 6/19/2018

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