Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
ATP13A2 belongs to the P-type superfamily of ATPases that transport inorganic cations and other substrates across cell membranes. ATP13A2 has predominantly neuronal expression and transiently transfected cells studies have shown that it is located in lysosomes. Recently a loss-of-function mutation in ATP13A2 has been linked to an autosomal recessive form of early-onset parkinsonism with pyramidal degeneration and dementia.
Anti-ATP13A2 antibody IHC staining of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B11104 dilution 1:100. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Detection of ATP13A2 in mouse brain membrane lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.