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Anti-ATM Antibody (aa980-1512, clone 3E8) IHC-plus™ LS-B1684

Note: This antibody replaces LS-C19925
Catalog Size Price
LS-B1684-50 50 µl (1 mg/ml) Unavailable

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100% Guaranteed
Mouse Monoclonal [clone 3E8] (IgG1) to Human ATM
Human
IHC - Paraffin, Western blot, Immunoprecipitation
Unconjugated

Details

Human ATM
Mouse
Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [3E8]
Unconjugated
Protein G purified
Unmodified

Applications

  • IHC - Paraffin (5 µg/ml)
  • Western blot
  • Immunoprecipitation

Specificity and Use

ATM antibody was raised against recombinant human ATM.
aa980-1512
Recombinant protein expressed in E. coli corresponding to amino acids 980-1512.
Immunohistochemistry: LS-B1684 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B1684 was determined to be 5 ug/ml.

Packaging

PBS, pH 7.4. No preservatives added.
+4°C or -20°C, Avoid repeated freezing and thawing.
For research use only.

About ATM

Q13315 NM_000051 NP_000042.3

ATM Antibody, A-T mutated Antibody, ATA Antibody, ATC Antibody, ATD Antibody, ATE Antibody, AT mutated Antibody, Ataxia telangiectasia Antibody, ATDC Antibody, Serine-protein kinase ATM Antibody, AT1 Antibody, Ataxia telangiectasia mutated Antibody, TEL1 Antibody, TELO1 Antibody

Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism.

Immunohistochemistry

Immunohistochemistry
Anti-ATM antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1684 concentration 5 ug/ml.

Requested From: 
Date Requested: 10/20/2017

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