Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone 8D7] (IgG1) to Rat ASGR1 / ASGPR
IHC - Frozen, Immunofluorescence, Western blot, Flow Cytometry (applications tested for the base form of this product only)
Rat ASGR1 / ASGPR
Rat, Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [8D7]
IHC - Frozen
(applications tested for the base form of this product only)
Specificity and Use
ASGR1 / ASGPR antibody was raised against crude rat liver membrane extracts
For immunohistology (acetone fixed), flow cytometry and Western blotting dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.
ASGR1 / ASGPR is a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery.