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Anti-APP / Beta Amyloid Precursor Antibody (N-Terminus) LS-C312

Note: This antibody replaces LS-C42821

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Rabbit Polyclonal to Human APP / Beta Amyloid Precursor
Human, Mouse, Rat
IHC, Western blot
Unconjugated

Details

Human APP / Beta Amyloid Precursor
Rabbit
Human, Mouse, Rat (tested or 100% immunogen sequence identity)
Polyclonal
Immunoaffinity purified

Applications

IHC, Western blot (0.5 - 1 µg/ml)

Specificity and Use

APP / Beta Amyloid Precursor antibody was raised against synthetic peptide from human APP.
LS-E29898 - Liquid - 50 µg - $145.00
N-Terminus
Peptide corresponding to amino acids of human amyloid A4 protein precursor (APP) corresponding to the amino terminus of the 4K Ab peptide generated by b- and g-secretases The peptide sequences are identical to those of rabbit, pig, bovine, guinea pig, and chicken.

Packaging

PBS, 0.02% sodium azide.
Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
For research use only.

About APP / Beta Amyloid Precursor

P05067 NM_000484 NP_000475.1

APP Antibody, ABPP Antibody, A4 Antibody, ABETA Antibody, AD1 Antibody, Alzheimer disease Antibody, Amyloid beta Antibody, Beta-amyloid peptide Antibody, APPI Antibody, Beta amyloid Antibody, CVAP Antibody, AAA Antibody, PN2 Antibody, PreA4 Antibody, Amyloid beta A4 protein Antibody, Peptidase nexin-II Antibody, CTFgamma Antibody, PN-II Antibody, Protease nexin-II Antibody

Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP.

Immunohistochemistry

Immunohistochemistry
Immunohistochemistry of APP in human brain (Alzheimer's disease) tissue with APP antibody at 10 ug/ml.

Western blot

Western blot
Western blot of APP in human (A), mouse (B), and rat (C) brain tissue lysates with APP antibody at 1 ug/ml.

Requested From: United States
Date Requested: 9/26/2016

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