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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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APC Antibody (aa2020‑2069) LS‑C117827
APC antibody LS-C117827 is an unconjugated rabbit polyclonal antibody to human APC. Validated for IHC and Peptide-ELISA.
Catalog
Size
Price
LS-C117827-50
50 µl
Unavailable
LS-C117827-100
100 µl
Unavailable

Popular APC Products

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Anti-APC antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7592 dilution 1:100.
Species: Human, Mouse, Rat
Applications: IHC, IHC - Paraffin, Western blot, Peptide Enzyme-Linked Immunosorbent Assay
Western blot analysis of APC (pS2054) expression in HeLa (A); Caco2 (B); SW480 (C); MCF7 (D); SP2/0 (E); PC12 (F) whole cell lysates.
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Applications: Western blot
Immunohistochemical analysis of APC staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Species: Human, Rat, Bovine, Pig, Chicken
Applications: IHC, IHC - Paraffin, ICC, Immunofluorescence, Western blot
Western blot of APC antibody
Species: Human, Mouse, Rat
Applications: IHC, Immunofluorescence, Western blot, ELISA

Product Description

APC antibody LS-C117827 is an unconjugated rabbit polyclonal antibody to human APC. Validated for IHC and Peptide-ELISA.
About APC
Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. P25054 NM_000038 NP_000029.2

APC Antibody, Adenomatosis polyposis coli Antibody, Adenomatous polyposis coli Antibody, BTPS2 Antibody, Deleted in polyposis 2.5 Antibody, DP2 Antibody, DP2.5 Antibody, FPC Antibody, GS Antibody, Protein APC Antibody, PPP1R46 Antibody, DP3 Antibody


Specifications

Target
Human APC
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (1:50 - 1:100)
  • Peptide Enzyme-Linked Immunosorbent Assay (1:1000)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
APC antibody was raised against synthetic peptide from human APC (aa2020-2069).
Epitope
aa2020-2069
Specificity
APC (Ab-2054) Antibody detects endogenous levels of total APC protein.
Presentation
PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
Storage
Store at -20°C for up to 1 year.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Images


Immunohistochemistry

IHC of paraffin-embedded human brain, using APC (Ab-2054) Antibody. The picture on the right is treated with the synthesized peptide.
IHC of paraffin-embedded human brain, using APC (Ab-2054) Antibody. The picture on the right is treated with the synthesized peptide.

Immunohistochemistry

IHC of paraffin-embedded human brain, using APC (Ab-2054) Antibody. The picture on the right is treated with the synthesized peptide.
IHC of paraffin-embedded human brain, using APC (Ab-2054) Antibody. The picture on the right is treated with the synthesized peptide.

Immunohistochemistry

IHC of paraffin-embedded human brain, using APC (Ab-2054) Antibody. The picture on the right is treated with the synthesized peptide.
IHC of paraffin-embedded human brain, using APC (Ab-2054) Antibody. The picture on the right is treated with the synthesized peptide.

Immunohistochemistry

IHC of paraffin-embedded human brain, using APC (Ab-2054) Antibody. The picture on the right is treated with the synthesized peptide.
IHC of paraffin-embedded human brain, using APC (Ab-2054) Antibody. The picture on the right is treated with the synthesized peptide.


Requested From: 
Date Requested: 6/21/2018

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