Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
ANXA2 Antibody, Annexin A2 Antibody, Annexin-2 Antibody, ANX2 Antibody, Calpactin I heavy chain Antibody, Chromobindin-8 Antibody, CAL1H Antibody, Calpactin I heavy polypeptide Antibody, Chromobindin 8 Antibody, LPC2 Antibody, LIP2 Antibody, Lipocortin II Antibody, p36 Antibody, LPC2D Antibody, PAP-IV Antibody, Protein I Antibody, Annexin II Antibody, ANX2L4 Antibody, Calpactin-1 heavy chain Antibody
ANXA2 / Annexin A2 is a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively.
Annexin A2 in Human Liver. Annexin A2 was detected in immersion fixed paraffin-embedded sections of human liver using Mouse Anti-Human/Mouse/Rat Annexin A2 Monoclonal Antibody at 15 ug/ml overnight at 4°C. Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic. Tissue was stained using Anti-Mouse HRP-DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to plasma membranes and cytoplasm of hepatocytes.
Detection of Human, Mouse, and Rat Annexin A2 by Western Blot. Western blot shows lysates of HeLa human cervical epithelial carcinoma cell line, A431 human epithelial carcinoma cell line, C2C12 mouse myoblast cell line, and L6 rat myoblast cell line. PVDF Membrane was probed with 0.1 ug/ml of Mouse Anti-Human/Mouse/Rat Annexin A2 Monoclonal Antibody followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody. A specific band was detected for Annexin A2 at approximately 40 kD (as indicated). This experiment was conducted under reducing conditions.