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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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AML1 / RUNX1 Antibody (aa231‑245) LS‑C623
Note: This antibody replaces LS-C68909
RUNX1 antibody LS-C623 is an unconjugated rabbit polyclonal antibody to RUNX1 (AML1) from human, mouse, bovine and other species. Validated for WB.
Catalog
Size
Price
LS-C623-100
100 µg (0.5 mg/ml)
$335

Popular AML1 / RUNX1 Products

Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)
Species: Human, Mouse, Rat
Applications: IHC, IHC - Paraffin, ICC, Immunofluorescence, Western blot, Immunoprecipitation
Anti-RUNX1 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B998 concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Species: Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Guinea pig, Horse, Pig, Rabbit, Chicken, Zebrafish
Applications: IHC, IHC - Paraffin, Western blot
Antibody
Species: Human, Mouse, Rat
Applications: IHC, Western blot
Anti-RUNX1 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5382 concentration 5 ug/ml.
Species: Human
Applications: IHC, IHC - Paraffin, Immunofluorescence, Western blot, ELISA
Anti-AML1 / RUNX1 antibody IHC staining of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Species: Human
Applications: IHC, IHC - Paraffin, Immunofluorescence, Western blot, ELISA

Product Description

RUNX1 antibody LS-C623 is an unconjugated rabbit polyclonal antibody to RUNX1 (AML1) from human, mouse, bovine and other species. Validated for WB.
About AML1 / RUNX1
CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the mouse BLK promoter. Q01196 NM_001754 NP_001745.2

RUNX1 Antibody, AMLCR1 Antibody, Aml1 oncogene Antibody, AML1 Antibody, AML1-EVI-1 Antibody, CBF-alpha-2 Antibody, CBFA2 Antibody, Acute myeloid leukemia 1 Antibody, EVI-1 Antibody, PEBP2A2 Antibody, PEA2-alpha B Antibody, AML1-EVI-1 fusion protein Antibody, Oncogene AML-1 Antibody, PEBP2-alpha B Antibody, PEBP2aB Antibody


Specifications

Target
Human AML1 / RUNX1
Host
Rabbit
Reactivity
Human, Monkey, Mouse, Bovine, Dog, Horse, Pig (tested or 100% immunogen sequence identity)
Predicted
Rat, Hamster, Rabbit, Xenopus (at least 90% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Protein G purified
Modifications
Unmodified
Applications
  • Western blot (2 - 5 µg/ml)
Immunogen
AML1 / RUNX1 antibody was raised against a peptide corresponding to a sequence that is homologous in AML-1 and AML-1/ETO [amino acids 231 to 245 (AFNPQPQSQMQDTRQ) of human origin]. Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Gibbon, Monkey, Marmoset, Bovine, Dog, Panda, Horse, Pig (100%); Mouse, Rat, Hamster, Rabbit, Xenopus (93%); Elephant, Opossum (87%).
Epitope
aa231-245
Specificity
A peptide corresponding to a sequence that is homologous in AML-1 and AML-1/ETO (amino acids 231 to 245 of human origin).
Presentation
PBS, 0.02% Sodium Azide
Storage
Short term: 4°C; Long term: -70°C.
Restrictions
For research use only.

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Images

Western blot

Western blot ofAML-1 in (A) human Ramos and(B) mouse Raw cell lysate using antibody at5 ug/ml.
Western blot ofAML-1 in (A) human Ramos and(B) mouse Raw cell lysate using antibody at5 ug/ml.

Western blot

Western blot ofAML-1 in (A) human Ramos and(B) mouse Raw cell lysate using antibody at5 ug/ml.
Western blot ofAML-1 in (A) human Ramos and(B) mouse Raw cell lysate using antibody at5 ug/ml.

Western blot

Western blot ofAML-1 in (A) human Ramos and(B) mouse Raw cell lysate using antibody at5 ug/ml.
Western blot ofAML-1 in (A) human Ramos and(B) mouse Raw cell lysate using antibody at5 ug/ml.

Western blot

Western blot ofAML-1 in (A) human Ramos and(B) mouse Raw cell lysate using antibody at5 ug/ml.
Western blot ofAML-1 in (A) human Ramos and(B) mouse Raw cell lysate using antibody at5 ug/ml.

Requested From: United States
Date Requested: 9/23/2018

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