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The ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 molecules of delta-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins). ALAD catalyzes the second step in the porphyrin and heme biosynthetic pathway; zinc is essential for enzymatic activity. ALAD enzymatic activity is inhibited by lead and a defect in the ALAD structural gene can cause increased sensitivity to lead poisoning and acute hepatic porphyria.
Gene Name: | aminolevulinate dehydratase |
Synonyms: | ALAD, ALADH, Aminolevulinate dehydratase, PBGS, Porphobilinogen synthase |
Target Sequences: | NM_000031 NP_000022.3 P13716 |
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