Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone 57 (BGN/1388/66)] (IgG1) to Human ACTH
IHC - Paraffin, ELISA
Human, Rat (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [57 (BGN/1388/66)]
Protein A purified
IHC - Paraffin (1:100 - 1:200)
Specificity and Use
ACTH antibody was raised against keyhole Limpet Hemocyanin conjugated human ACTH (1-17).
(Clone 57, BGN/1388/66) recognizes 1-24 ACTH (Synacthen) which, as a synthetic analogue of naturally-occurring Adrenocorticotropic Hormone, can be used to measure adrenal reserve and for the diagnosis of adrenal insufficiency by acute adrenocortical stimulation. ACTH, released from the anterior pituitary gland in response to corticotropin-releasing hormone from the hypothalamus, acts on the adrenal cortex to stimulate the production of corticosteroids such as cortisol, involved in the response to stress. Studies have shown that the administration of 1-24 ACTH increases blood pressure, believed to be attributed to an increase in ACTH-stimulated cortisol secretion, in association with increased cardiac output. Does not recognize 17-39 ACTH (CLIP). It does cross-reacts with rat N-terminal ACTH.
Immunohistology: This product requires protein digestion pre-treatment of paraffin sections, e. g. trypsin or pronase.