Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone F4] (IgG1) to Hamster ABCB1 / MDR1 / P Glycoprotein
IHC - Paraffin, Immunofluorescence, Western blot, Flow Cytometry
Hamster ABCB1 / MDR1 / P Glycoprotein
Hamster, Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [F4]
Protein G purified
IHC - Paraffin (20 µg/ml)
Western blot (1 - 2 µg/ml)
Specificity and Use
ABCB1 / MDR1 / P Glycoprotein antibody was raised against human and hamster drug-resistant viable cells followed by crude plasma membranes.
Extracellular amino terminal half This epitope is resistant to formalin fixation and periodate oxidation and is different from those of other commonly known MAbs to P-glycoprotein, such as C219, JSB-1, and MRK16, which recognize an intracellular and extracellular epitope of P-glycoprotein, respectively.
10mM PBS, pH 7.4, with 0.2% BSA and 0.09% Sodium Azide
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance.