LSBio
Human NGFR / CD271 / TNR16 Protein (Recombinant)

Human NGFR / CD271 / TNR16 Protein (Recombinant)

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Expression SystemHuman Embryonic Kidney 293
Format:Lyophilized
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$268.00each
Catalog Number: LS-G27179-10

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Overview

Description
NGF Receptor, also known as Gp80-LNGFR, p75 ICD, CD271 and TNFRSF16, is a type I transmembrane protein belonging to the TNF receptor family. It is expressed by both neuronal and non-neuronal cells. Signaling through NGF Receptor has been shown to regulate gene expression, cell migration and death. A truncated NGF Receptor containing only the extracellular domain has been detected in plasma, amniotic fluid and urine, and acts as a potent NGF antagonist.
Category
Proteins & Peptides > Proteins > Recombinant Proteins
Alternative Names
CD271 | CD271 antigen | gp80-LNGFR | Nerve growth factor receptor | p75 ICD | p75(NTR) | p75NTR | TNFR superfamily | member 16 | NGF receptor | NGFR | TNFRSF16 | p75-NTR
Origin Species
Human
NCBI GenBank
NM_002507|NP_002498.1
SwissProt
P08138

Protein

Expression System
Human Embryonic Kidney 293
Molecular Weight
32-60 kDa (SDS-PAGE)
Protein Type
Recombinant
Amino Acid Sequence
1KEACPTGLYT HSGECCKACN LGEGVAQPCG ANQTVCEPCL DSVTFSDVVS ATEPCKPCTE
61CVGLQSMSAP CVEADDAVCR CAYGYYQDET TGRCEACRVC EAGSGLVFSC QDKQNTVCEE
121CPDGTYSDEA NHVDPCLPCT VCEDTERQLR ECTRWADAEC EEIPGRWITR STPPEGSDST
181APSTQEPEAP PEQDLIASTV AGVVTTVMGS SQPVVTRGTT DN

222 aa

Format

Purity
>95%
Conjugate/Label
Unconjugated
Endotoxin Level
< 0.2 EU/µg
Format
Lyophilized
Formulation
Lyophilized from PBS
Purity Measurement Method
SDS-PAGE (Coomassie Stain)

Storage & Handling

Storage Conditions
Stable at -80°c for up to 6 months. Upon reconstitution, store at 4°c for up to 1 week or at -20°c for up to 2 months.
Specific Activation of the CD271 Intracellular Domain in Combination with Chemotherapy or Targeted Therapy Inhibits Melanoma Progression. Annalisa Saltari, Andreas Dzung, Marika Quadri, Natascia Tiso, Nicola Facchinello, Alberto Hernández-Barranco, Susana Garcia-Silva, Laura Nogués, Corinne Isabelle Stoffel, Phil F Cheng, Patrick Turko, Ossia M Eichhoff, Francesca Truzzi , Alessandra Marconi, Carlo Pincelli, Héctor Peinado, Reinhard Dummer, Mitchell P Levesque. The Breast : official journal of the European Society of Mastology. 2021 Dec;81:6044-6057. PubMed: 34645608
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