TLR4 Antibody (clone HTA125, Concentrated)

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Antibody:	Mouse Monoclonal
Applications:	Flow Cytometry, Immunohistochemistry (general), Immunoprecipitation
Reactivity:	Human
Format:	Liquid

$542.00each

Catalog Number: LS-C134837-1

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Description: TLR4 antibody LS-C134837 is an unconjugated mouse monoclonal antibody to human TLR4. Validated for Flow and IP.
Application: FC, IHC, IP
Reactivity: Hu
Intended Use: Research Use Only
Guarantees: This antibody carries the LSBio 100% Guarantee. ✓
Category: Antibodies > Primary Antibodies > Monoclonal Antibodies
Alternative Names: CD284 | CD284 antigen | Homolog of Drosophila toll | TLR-4 | TOLL | ARMD10 | TLR4 | Toll-like receptor 4 | HToll
UniProt Number: O00206
NCBI GenBank: NM_138554
SwissProt: O00206

Target: Human TLR4
Antigen Species: Human
Epitope: Toll-like receptors (TLR) are highly conserved throughout evolution and have been implicated in the innate defense to many pathogens. In Drosophila toll is required for the anti-fungal response, while the related 18-wheeler is involved in antibacterial defenses. In mammals, TLR identified as type I transmembrane signaling receptors with pattern recognition capabilities, have been implicated in the innate host defense to pathogens. TLR4 has been identified next to MD-2 and CD14 as a receptor that is central to the innate immune response to lipopolysaccharides (LPS) of Gram-negative bacteria. The HTA125 monoclonal antibody reacts preferentially, especially in flow cytometry, with human TLR4 that is associated with MD-2. HTA125 is a TLR4 function-blocking antibody that is useful for studies on the role of TLR4 as a receptor for LPS induced cytokine production by TLR4 bearing cells. The antibody was shown to precipitate TLR4 (100 kD).
Gene Name: TLR4