Anti-SIRT1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
SIRT1 / Sirtuin 1 Antibody (aa207-256)
| Antibody: | Rabbit Polyclonal |
| Applications: | Immunohistochemistry (general), Immunohistochemistry, Paraffin, Western Blot |
| Reactivity: | Human |
| Format: | Liquid |
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- Description
- Sirtuin 1 antibody LS-B1564 is an unconjugated rabbit polyclonal antibody to human Sirtuin 1 (SIRT1) (aa207-256). Validated for IHC and WB. Cited in 4 publications.
- Application
- IHC, IHC-P, WB
- Reactivity
- Hu
- Intended Use
- Research Use Only
- Guarantees
- This product carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Polyclonal Antibodies
- Alternative Names
- SIR2-like protein 1 | SIR2alpha | SIR2L1 | Sirtuin 1 | Sir2-like 1 | SIRT1 | Sirtuin type 1 | HSIR2 | HSIRT1
- Recommended Dilution: IHC-P
- 5 µg/ml
- Recommended Dilution: WB
- 0.5 µg/ml
- UniProt Number
- Q96EB6
- NCBI GenBank
- NM_012238 | NP_036370.2
- SwissProt
- Q96EB6
Target
- Target
- SIRT1 / Sirtuin 1
- Antigen Species
- Human
- Specificity
- human SIRT1
- Epitope
- human SIRT1
- Gene Name
- SIRT1
Antibody
- Host Species
- Rabbit
- Clonality
- Polyclonal
- Origin Species
- Human
Immunogen
- Immunogen
- Synthetic peptide located between aa207-256 of human SIRT1 (Q96EB6, NP_036370). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Gibbon, Monkey, Galago, Marmoset, Mouse, Rat, Elephant, Dog, Bovine, Bat, Rabbit, Horse, Pig, Guinea pig (100%); Turkey, Xenopus (92%); Chicken (85%); Zebrafish (84%).
- Immunogen Type
- Synthetic Peptide (Linear)
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- PBS, 0.09% sodium azide, 2% sucrose
- Concentration
- 0.5 mg/mL
- Volume
- 100 Microliter
- Animal Free
- No
- Carrier-Free
- Yes
- Preservative
- Yes
- Purification Method
- Affinity Purified
Storage & Handling
- Storage Conditions
- Short term: Store at 2-8°C. Long term: Aliquot and store at -20°C. Avoid freeze/thaw cycles.
- Recommended Storage Buffer
- PBS
Notochordal cell disappearance and modes of apoptotic cell death in a rat tail static compression-induced disc degeneration model. Yurube T, Hirata H, Kakutani K, Maeno K, Takada T, Zhang Z, Takayama K, Matsushita T, Kuroda R, Kurosaka M, Nishida K. Arthritis research & therapy. 2014;16:R31.
PubMed: 24472667 · PMC: PMC3979117
Age-dependent increase in miRNA-34a expression in the posterior pole of the mouse eye. Smit-McBride Z, Forward KI, Nguyen AT, Bordbari MH, Oltjen SL, Hjelmeland LM. Molecular vision. 20:1569-78.
PubMed: 25489229 · PMC: PMC4225137
Restoration of perivascular adipose tissue function in diet-induced obese mice without changing bodyweight. Xia N, Weisenburger S, Koch E, Burkart M, Reifenberg G, Förstermann U, Li H. British journal of pharmacology. 2017;174:3443-3453.
PubMed: 28055105 · PMC: PMC5610154
The Involvement of Sirtuin 1 Dysfunction in High-Fat Diet-Induced Vascular Dysfunction in Mice. Ning Xia, Gisela Reifenberg, Christian Schirra, Huige Li. Antioxidants (Basel, Switzerland). 2022 March;11.
PubMed: 35326191 · PMC: PMC8944782