SIGLEC1 / CD169 / Sialoadhesin Antibody (clone 3B11/11)
Primary AntibodyLSBio Guarantee
| Antibody: | Mouse Monoclonal |
| Applications: | Flow Cytometry, Immunohistochemistry (general), Immunohistochemistry, Frozen, Immunoprecipitation, Western Blot |
| Reactivity: | Pig |
| Format: | Liquid |
$363.00each
Catalog Number: LS-C187491-0.1
Catalog Number: LS-C187491
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- Description
- Sialoadhesin antibody LS-C187491 is an unconjugated mouse monoclonal antibody to pig Sialoadhesin (SIGLEC1 / CD169). Validated for Flow, IHC, IP and WB. Cited in 1 publication.
- Application
- FC, IHC, IHC-F, IP, WB
- Reactivity
- Por
- Intended Use
- Research Use Only
- Guarantees
- This antibody carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Monoclonal Antibodies
- Alternative Names
- CD169 | CD169 antigen | SIGLEC-1 | SIGLEC1 | Sialoadhesin | SN | DJ1009E24.1
- UniProt Number
- Q9BZZ2
- NCBI GenBank
- NM_023068 | NP_075556.1
- SwissProt
- Q9BZZ2
Target
- Target
- Pig SIGLEC1 / CD169 / Sialoadhesin
- Antigen Species
- Pig
- Epitope
- Porcine CD169, also known as sialoadhesin or Siglec-1, a member of the sialic acid binding immunoglobulin-like lectin (Siglec) family. CD169 was originally identified in mice and identified as the sialic acid dependent Sheep erythrocyte receptor. CD169 has subsequently been identified in rat, human and pig. Was originally raised as part of a panel of anti porcine macrophage monoclonal antibodies raised against isolated porcine alveolar macrophages. Immunohistochemical analysis indicated restriction to macrophage populations mainly in the spleen, lymph nodes, liver and Peyer's patches. Originally described as a non phagocytic intercellular adhesion receptor, work on porcine CD169 indicated that it may play a role as a viral adhesion receptor and as a targeted receptor for the delivery of toxins and antigens. Detects a band of approximately 190 kD in alveolar macrophage extracts under non-reducing conditions.
- Gene Name
- SIGLEC1
Antibody
- Host Species
- Mouse
- Clonality
- Monoclonal
- Clone
- 3B11/11
- Isotype
- IgG1
Immunogen
- Immunogen
- Porcine alveolar macrophages.
- Immunogen Type
- Cell-Based Immunization
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- PBS, 0.09% Sodium Azide
- Concentration
- 1 mg/mL
- Preservative
- Yes
- Purification Method
- Protein G Affinity
Storage & Handling
- Storage Conditions
- Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
- Recommended Storage Buffer
- PBS
Porcine sialoadhesin suppresses type I interferon production to support porcine reproductive and respiratory syndrome virus infection. Yingqi Liu, Rui Li, Songlin Qiao, Xin-Xin Chen, Ruiguang Deng, Gaiping Zhang. Veterinary Research. 2020 February;51:18. PubMed: 32093750 PMC: PMC7038599