Polyclonal Rabbit anti-Human SLC5A11 / SMIT2 Antibody (WB)
Catalog Number: LS-C748223
2 sizes / from $281.00
Antibody: Rabbit Polyclonal
Applications: Immunohistochemistry (general), Western Blot
Reactivity: Human, Mouse, Rat
Format: Liquid
Formalin-fixed, paraffin-embedded section of dog ischemic brain stained for Active/Cleaved Caspase-3 expression using Polyclonal Antibody to Active/Cleaved Caspase-3 at 1:2000. Staining is seen in the nuclei of dying neurons (black arrow) but not in the morphologically normal nuclei (open arrows). Caspase-3 expression in the nucleus is considered to be a marker of active/caspase-3 expression and apoptosis. Hematoxylin-Eosin counterstain.
Polyclonal Rabbit anti-Human CASP3 / Caspase 3 Antibody (IHC, WB)
Primary AntibodyLSBio Guarantee
| Antibody: | Rabbit Polyclonal |
| Applications: | Immunohistochemistry (general), Immunohistochemistry, Frozen, Immunohistochemistry, Paraffin, Immunoprecipitation, Western Blot |
| Reactivity: | Human, Mammal (Other), Mouse, Rat |
| Format: | Liquid |
$394.00each
Catalog Number: LS-C148242-50
Catalog Number: LS-C148242
For bulk orders or custom formulations:
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- Description
- Caspase 3 antibody LS-C148242 is an unconjugated rabbit polyclonal antibody to Caspase 3 (CASP3) from human. It is reactive with human, mouse, rat and other species. Validated for IHC, IP and WB. Cited in 1 publication.
- Application
- IHC, IHC-F, IHC-P, IP, WB
- Reactivity
- Hu, Mml, Ms, Rt
- Intended Use
- Research Use Only
- Guarantees
- This antibody carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Polyclonal Antibodies
- Alternative Names
- Apopain | CASP-3 | CASP3 | Caspase-3 | CPP32B | CPP32 | Cysteine protease CPP32 | SCA-1 | SREBP cleavage activity 1 | Yama | Procaspase3 | Caspase 3 | CPP-32 | PARP cleavage protease | Protein Yama
- Recommended Dilution: IHC-P
- 1:1000 - 1:5000
- Recommended Dilution: IP
- 1:50 - 1:200
- Recommended Dilution: WB
- 1:1000 - 1:2000
- UniProt Number
- P42574
- NCBI GenBank
- NM_004346 | NP_004337.2
- SwissProt
- P42574
Target
- Target
- Human CASP3 / Caspase 3
- Antigen Species
- Human
- Epitope
- Preferentially detects active caspase-3 (large subunit: ~14-21 kD, and small subunit: ~10 kD). However, it may also detect pro-caspase-3 (~32 kD) in some cell or tissue systems. Nuclear immunostaining of caspase-3 is considered be an indication of active/cleaved caspase-3.
- Gene Name
- CASP3
Antibody
- Host Species
- Rabbit
- Clonality
- Polyclonal
Immunogen
- Immunogen
- Recombinant catalytically active human caspase-3 protein.
- Immunogen Type
- Recombinant Immunogen
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- Antiserum, 0.05% sodium azide
- Volume
- 50 Microliter
- Preservative
- Yes
- Purification Method
- Unpurified (Serum / Ascites / Supernatant)
Storage & Handling
- Storage Conditions
- Store at -20°C. Aliquot to avoid freeze/thaw cycles.
In-frame deletion in canine PITRM1 is associated with a severe early-onset epilepsy, mitochondrial dysfunction and neurodegeneration10 Research Programs Unit, Stem Cells and Metabolism Research Program, University of Helsinki, Helsinki, Finland12 Department of Neurology, Neuro-SysMed, Haukeland University Hospital, Bergen, Norway14 Folkhälsan Research Center, Helsinki, Finland. hannes.lohi@helsinki.fi. Marjo K Hytönen , Riika Sarviaho , Christopher B Jackson, Pernilla Syrjä, Tarja Jokinen , Kaspar Matiasek, Marco Rosati, Cristina Dallabona, Enrico Baruffini, Ileana Quintero , Meharji Arumilli , Geoffray Monteuuis, Jonas Donner, Marjukka Anttila, Anu Suomalainen, Laurence A Bindoff , Hannes Lohi. Human genetics. 2021 Nov;;140:1593-1609. PubMed: 33835239 PMC: PMC8519929
