GPER1 / GPR30 Antibody
Catalog Number: LS-C779160-100
100 µL / $365.00
Antibody: Rabbit Polyclonal
Applications: Enzyme-Linked Immunosorbent Assay, Western Blot
Reactivity: Human, Mouse, Rat
Format: Liquid
Anti-GPR30 antibody IHC of human brain, hippocampus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
PathPlus™ GPER1 / GPR30 Antibody (Extracellular Domain)
Primary AntibodyLSBio Guarantee
| Antibody: | Rabbit Polyclonal |
| Applications: | Immunohistochemistry (general) |
| Reactivity: | Human, Non-Human Primate |
| Format: | Liquid |
$449.00each
Catalog Number: LS-A4271-50
Catalog Number: LS-A4271
For bulk orders or custom formulations:
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- Description
- GPR30 antibody LS-A4271 is an unconjugated rabbit polyclonal antibody to GPR30 (GPER1) (Extracellular Domain) from human. It is reactive with human and monkey. Validated for IF, IHC and WB. Cited in 8 publications.
- Application
- IHC
- Reactivity
- Hu, NHP
- Predicted Reactivity
- Dog, Hamster, Mouse, Rat
- Intended Use
- Research Use Only
- Guarantees
- This product carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Polyclonal Antibodies
- Alternative Names
- CMKRL2 | CEPR | FEG-1 | G-protein coupled receptor 30 | G protein-coupled receptor 30 | GPCR-Br | GPER | Heptahelix receptor | LERGU | LyGPR | MER | GPR30 | IL8-related receptor DRY12 | LERGU2 | Chemokine receptor-like 2 | DRY12 | Membrane estrogen receptor
- Recommended Dilution: IHC-P
- 6.4 µg/ml
- UniProt Number
- Q99527
- NCBI GenBank
- NM_001505 | NP_001496.1
- SwissProt
- Q99527
Target
- Target
- GPER1 / GPR30
- Antigen Species
- Human
- Specificity
- Human GPR30. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
- Epitope
- Human GPR30. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
- Gene Name
- GPER1
Antibody
- Host Species
- Rabbit
- Clonality
- Polyclonal
Immunogen
- Immunogen
- Synthetic 16 amino acid peptide from 3rd extracellular domain of human GPR30. Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey, Marmoset (100%); Mouse, Rat, Hamster, Elephant, Dog, Opossum (94%); Panda, Bat, Horse, Rabbit, Platypus (88%).
- Immunogen Type
- Synthetic Peptide (Linear)
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- PBS, 0.1% Sodium Azide
- Concentration
- 1 mg/mL
- Animal Free
- No
- Carrier-Free
- Yes
- Preservative
- Yes
- Purification Method
- Affinity Purified
Storage & Handling
- Storage Conditions
- Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
- Recommended Storage Buffer
- PBS
Identification of the estrogen receptor GPER in neoplastic and non-neoplastic human testes. Rago V, Romeo F, Giordano F, Maggiolini M, Carpino A. Reproductive biology and endocrinology : RB&E. 2011;9:135.
PubMed: 21974818 · PMC: PMC3200171
Nuclear alternate estrogen receptor GPR30 mediates 17beta-estradiol-induced gene expression and migration in breast cancer-associated fibroblasts. Madeo A, Maggiolini M. Cancer research. 2010 Jul;70:6036-46.
PubMed: 20551055
Identification of G protein-coupled estrogen receptor in human and pig spermatozoa. Rago V, Giordano F, Brunelli E, Zito D, Aquila S, Carpino A. Journal of anatomy. 2014 Jun;224:732-6.
PubMed: 24697543
Expression pattern of G protein-coupled receptor 30 in LacZ reporter mice. Isensee J, Meoli L, Zazzu V, Nabzdyk C, Witt H, Soewarto D, Effertz K, Fuchs H, Gailus-Durner V, Busch D, Adler T, de Angelis MH, Irgang M, Otto C, Noppinger PR. Endocrinology. 2009 Apr;150:1722-30.
PubMed: 19095739
G protein-coupled receptor 30 expression is up-regulated by EGF and TGF alpha in estrogen receptor alpha-positive cancer cells. Vivacqua A, Lappano R, De Marco P, Sisci D, Aquila S, De Amicis F, Fuqua SA, And[Character f2] S, Maggiolini M. Molecular endocrinology (Baltimore, Md.). 2009 Nov;23:1815-26.
PubMed: 19749156
c-Jun activation is required for 4-hydroxytamoxifen-induced cell death in breast cancer cells. Madeo A, Vinciguerra M, Lappano R, Galgani M, Gasperi-Campani A, Maggiolini M, Musti AM. Oncogene. 2010 Feb;29:978-91.
PubMed: 19935718
Stallion spermatozoa: putative target of estrogens; presence of the estrogen receptors ESR1, ESR2 and identification of the estrogen-membrane receptor GPER. Arkoun B, Gautier C, Delalande C, Barrier-Battut I, Gu[Character e9]non I, Goux D, Boura[Character ef]ma-Lelong H. General and comparative endocrinology. 2014 May;200:35-43.
PubMed: 24607572
Estriol acts as a GPR30 antagonist in estrogen receptor-negative breast cancer cells. Lappano R, Rosano C, De Marco P, De Francesco EM, Pezzi V, Maggiolini M. Molecular and cellular endocrinology. 2010 May;320:162-70.
PubMed: 20138962
